Adult skeletal muscle has a remarkable ability to regenerate following myotrauma. Because
adult myofibers are terminally differentiated, the regeneration of skeletal muscle is largely …

We report on the formation and early differentiation of the somites in the avian embryo. The
somites are derived from the mesoderm which, in the body (excluding the head), is …

The growth and repair of skeletal muscle after birth depends on satellite cells that are
characterized by the expression of Pax7. We show that Pax3, the paralogue of Pax7, is also …

Abstract We analyzed Pax-3 (splotch) Myf-5 (targeted with nlacZ), and splotch/Myf-5
homozygous mutant mice to investigate the roles that these genes play in programming …

Somatic stem cell populations participate in the development and regeneration of their host
tissues. Skeletal muscle is capable of complete regeneration due to stem cells that reside in …

A number of developmental processes that involve cell migration, growth or morphogenesis
depend on extracellular signals. A molecule that provides such signals, known as …

Gene targeting has allowed the dissection of complex biological processes at the genetic
level. Our understanding of the nuances of skeletal muscle development has been greatly …

Introduction 3. Development and determination of the myogenic lineage 3.1. Somitogenesis:
formation of epaxial versus hypaxial musculature 3.2. The myogenic regulatory factors 3.2 …

Limb muscles in vertebrates originate from dermomyotomal cells, which during early
development migrate from the ventrolateral region of somites into the limb buds. These …

The segmented mesoderm in vertebrates gives rise to a variety of cell types in the embryo
including the axial skeleton and muscle. A number of transcription factors containing a …