Genetic mutations and abnormal gene regulation are key mechanisms underlying
tumorigenesis. Nucleosomes, which consist of DNA wrapped around histone cores …

The tumor suppressor and transcription factor p53 plays critical roles in tumor prevention by
orchestrating a wide variety of cellular responses, including damaged cell apoptosis …

Glioblastoma (GBM) is a highly malignant brain tumor characterized by a heterogeneous
population of genetically unstable and highly infiltrative cells that are resistant to …

Diffuse midline glioma (DMG) is a deadly pediatric and adolescent central nervous system
(CNS) tumor localized along the midline structures of the brain atop the spinal cord. With a …

Diffuse midline glioma (DMG) is a uniformly fatal pediatric cancer driven by oncohistones
that do not readily lend themselves to drug development. To identify druggable targets for …

Epigenetic enzymes histone deacetylases (HDACs) are clinically validated anticancer drug
targets which have been studied intensively in the past few decades. Although several drugs …

Pediatric high-grade glioma (pHGG) is a major contributor to cancer-related death in
children. In vitro and in vivo disease models reflecting the intimate connection between …

The efficacy of therapeutics for brain tumors is seriously hampered by multiple barriers to
drug delivery, including severe destabilizing effects in the blood circulation, the blood–brain …

Abstract Purpose: Adavosertib (AZD1775), an inhibitor of WEE1 kinase, potentiates
replicative stress induced by oncogenes or chemotherapy. Antitumor activity of adavosertib …

Small cell lung cancer (SCLC) continues to cause poor clinical outcomes due to limited
advances in sustained treatments for rapid cancer cell proliferation and progression. The …