C–H activation
T Rogge, N Kaplaneris, N Chatani, J Kim… - Nature Reviews …, 2021 - nature.com
Transition metal-catalysed C–H activation has emerged as an increasingly powerful platform
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
for molecular syntheses, enabling applications to natural product syntheses, late-stage …
Late‐stage peptide diversification by position‐selective C− H activation
The late‐stage modification of structurally complex peptides bears great potential for drug
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
discovery, crop protection, and the pharmaceutical industry, among others. Whereas …
Manganese‐Catalyzed C− H Alkynylation: Expedient Peptide Synthesis and Modification
Z Ruan, N Sauermann, E Manoni… - Angewandte …, 2017 - Wiley Online Library
Abstract Manganese (I)‐catalyzed C− H alkynylations with organic halides occurred with
unparalleled substrate scope, and thus enabled step‐economical C− H functionalizations …
unparalleled substrate scope, and thus enabled step‐economical C− H functionalizations …
Cyclic hypervalent iodine reagents: enabling tools for bond disconnection via reactivity umpolung
Conspectus The efficient synthesis of organic compounds is an important field of research,
which sets the basis for numerous applications in medicine or materials science. Based on …
which sets the basis for numerous applications in medicine or materials science. Based on …
Postassembly modifications of peptides via metal-catalyzed C–H functionalization
The growing importance of peptides and proteins in therapeutic and biomedical applications
has provided immense motivation toward the development of new ways to construct and …
has provided immense motivation toward the development of new ways to construct and …
Progress and perspectives on directing group-assisted palladium-catalysed C–H functionalisation of amino acids and peptides
Peptide modifications can unlock a variety of compounds with structural diversity and
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …
abundant biological activity. In nature, peptide modifications, such as functionalisation at the …
C‐Terminal Bioconjugation of Peptides through Photoredox Catalyzed Decarboxylative Alkynylation
M Garreau, F Le Vaillant, J Waser - Angewandte Chemie …, 2019 - Wiley Online Library
We report the first decarboxylative alkynylation of the C‐terminus of peptides starting from
free carboxylic acids. The reaction is fast, metal‐free, and proceeds cleanly to afford …
free carboxylic acids. The reaction is fast, metal‐free, and proceeds cleanly to afford …
Gold and hypervalent iodine (III): liaisons over a decade for electrophilic functional group transfer reactions
Over the last two decades, hypervalent iodine (III) reagents have evolved from being
'bonding curiosities' to mainstream reagents in organic synthesis, in particular, electrophilic …
'bonding curiosities' to mainstream reagents in organic synthesis, in particular, electrophilic …
Late‐Stage Peptide Diversification through Cobalt‐Catalyzed C− H Activation: Sequential Multicatalysis for Stapled Peptides
Bioorthogonal late‐stage diversification of structurally complex peptides has enormous
potential for drug discovery and molecular imaging. In recent years, transition‐metal …
potential for drug discovery and molecular imaging. In recent years, transition‐metal …
BODIPY Peptide Labeling by Late‐Stage C(sp3)−H Activation
Late‐stage BODIPY diversification of structurally complex amino acids and peptides was
accomplished by racemization‐free palladium‐catalyzed C (sp3)− H activation …
accomplished by racemization‐free palladium‐catalyzed C (sp3)− H activation …