Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation

Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …

Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin

T Dechat, K Pfleghaar, K Sengupta, T Shimi… - Genes & …, 2008 - genesdev.cshlp.org
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …

Nuclear lamins

T Dechat, SA Adam, P Taimen… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …

Nuclear lamins: laminopathies and their role in premature ageing

JLV Broers, FCS Ramaekers, G Bonne… - Physiological …, 2006 - journals.physiology.org
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …

Lamins in the nuclear interior− life outside the lamina

N Naetar, S Ferraioli, R Foisner - Journal of cell science, 2017 - journals.biologists.com
Nuclear lamins are components of the peripheral lamina that define the mechanical
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …

Essential Roles for Caenorhabditis elegans Lamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes

J Liu, TR Ben-Shahar, D Riemer… - Molecular biology of …, 2000 - Am Soc Cell Biol
Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa …

Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension

TO Ihalainen, L Aires, FA Herzog, R Schwartlander… - Nature materials, 2015 - nature.com
Nuclear lamins play central roles at the intersection between cytoplasmic signalling and
nuclear events. Here, we show that at least two N-and C-terminal lamin epitopes are not …

Nuclear lamins: key regulators of nuclear structure and activities

M Prokocimer, M Davidovich… - Journal of cellular …, 2009 - Wiley Online Library
• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …

Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries

A Bizhanova, PD Kaufman - Biochimica et Biophysica Acta (BBA)-Gene …, 2021 - Elsevier
Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …

Nuclear envelope dysfunction and its contribution to the aging process

F Martins, J Sousa, CD Pereira… - Aging cell, 2020 - Wiley Online Library
The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a
genome protective barrier and mechanotransduction interface between the cytoplasm and …