Lamins: nuclear intermediate filament proteins with fundamental functions in nuclear mechanics and genome regulation
Y Gruenbaum, R Foisner - Annual review of biochemistry, 2015 - annualreviews.org
Lamins are intermediate filament proteins that form a scaffold, termed nuclear lamina, at the
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
nuclear periphery. A small fraction of lamins also localize throughout the nucleoplasm …
Nuclear lamins: major factors in the structural organization and function of the nucleus and chromatin
T Dechat, K Pfleghaar, K Sengupta, T Shimi… - Genes & …, 2008 - genesdev.cshlp.org
Over the past few years it has become evident that the intermediate filament proteins, the
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …
types A and B nuclear lamins, not only provide a structural framework for the nucleus, but …
Nuclear lamins
T Dechat, SA Adam, P Taimen… - Cold Spring …, 2010 - cshperspectives.cshlp.org
The nuclear lamins are type V intermediate filament proteins that are critically important for
the structural properties of the nucleus. In addition, they are involved in the regulation of …
the structural properties of the nucleus. In addition, they are involved in the regulation of …
Nuclear lamins: laminopathies and their role in premature ageing
It has been demonstrated that nuclear lamins are important proteins in maintaining cellular
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …
as well as nuclear integrity, and in maintaining chromatin organization in the nucleus …
Lamins in the nuclear interior− life outside the lamina
Nuclear lamins are components of the peripheral lamina that define the mechanical
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …
properties of nuclei and tether heterochromatin to the periphery. A-type lamins localize also …
Essential Roles for Caenorhabditis elegans Lamin Gene in Nuclear Organization, Cell Cycle Progression, and Spatial Organization of Nuclear Pore Complexes
J Liu, TR Ben-Shahar, D Riemer… - Molecular biology of …, 2000 - Am Soc Cell Biol
Caenorhabditis elegans has a single lamin gene, designated lmn-1 (previously termed
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa …
CeLam-1). Antibodies raised against the lmn-1 product (Ce-lamin) detected a 64-kDa …
Differential basal-to-apical accessibility of lamin A/C epitopes in the nuclear lamina regulated by changes in cytoskeletal tension
TO Ihalainen, L Aires, FA Herzog, R Schwartlander… - Nature materials, 2015 - nature.com
Nuclear lamins play central roles at the intersection between cytoplasmic signalling and
nuclear events. Here, we show that at least two N-and C-terminal lamin epitopes are not …
nuclear events. Here, we show that at least two N-and C-terminal lamin epitopes are not …
Nuclear lamins: key regulators of nuclear structure and activities
M Prokocimer, M Davidovich… - Journal of cellular …, 2009 - Wiley Online Library
• The lamin molecule‐Domain organization of lamins‐Lamins are divided to type A and type
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …
B‐Post‐translational processing of lamin molecules‐Lamin molecules in evolution• The …
Close to the edge: Heterochromatin at the nucleolar and nuclear peripheries
A Bizhanova, PD Kaufman - Biochimica et Biophysica Acta (BBA)-Gene …, 2021 - Elsevier
Chromatin is a dynamic structure composed of DNA, RNA, and proteins, regulating storage
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
and expression of the genetic material in the nucleus. Heterochromatin plays a crucial role …
Nuclear envelope dysfunction and its contribution to the aging process
F Martins, J Sousa, CD Pereira… - Aging cell, 2020 - Wiley Online Library
The nuclear envelope (NE) is the central organizing unit of the eukaryotic cell serving as a
genome protective barrier and mechanotransduction interface between the cytoplasm and …
genome protective barrier and mechanotransduction interface between the cytoplasm and …