Opioids are used for pain management despite the side effects that contribute to the opioid
crisis. The pursuit of non-addictive opioid analgesics remains unattained due to the …

Stress is an essential adaptive response that enables the organism to cope with challenges
and restore homeostasis. Different stressors require distinctive corrective responses in …

Systemic sclerosis (scleroderma, SSc) is an incurable autoimmune disease with high
morbidity and mortality rates. Here, we conducted a population-scale single-cell genomic …

G protein-coupled receptors (GPCRs) activate G proteins and undergo a complex regulation
by interaction with GPCR kinases (GRKs) and the formation of receptor–arrestin complexes …

Carvedilol is among the most effective β-blockers for improving survival after myocardial
infarction. Yet the mechanisms by which carvedilol achieves this superior clinical profile are …

Both CXC chemokine receptor 4 (CXCR4) and atypical chemokine receptor 3 (ACKR3) are
activated by the chemokine CXCL12 yet evoke distinct cellular responses. CXCR4 is a …

GPCRs modulate a plethora of physiological processes and mediate the effects of one‐third
of FDA‐approved drugs. Depending on which ligand activates a receptor, it can engage …

Numerous clinical studies have revealed the utility of circulating AM (adrenomedullin) or MR-
proAM (mid-regional proAM 45-92) as an effective prognostic and diagnostic biomarker for a …

Atypical chemokine receptor 3 (ACKR3), formerly referred to as CXCR7, is considered to be
an interesting drug target. In this study, we report on the synthesis, pharmacological …

Elevated expression of the chemokine receptors CXCR4 and ACKR3 and of their cognate
ligand CXCL12 is detected in a wide range of tumors and the tumor microenvironment …