[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery

CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …

Targeting antioxidants for cancer therapy

A Glasauer, NS Chandel - Biochemical pharmacology, 2014 - Elsevier
Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …

[HTML][HTML] Src: coordinating metabolism in cancer

SG Pelaz, A Tabernero - Oncogene, 2022 - nature.com
Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during
proliferation, migration, stemness and differentiation. Src is a node of several signals …

[HTML][HTML] Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions

J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …

[HTML][HTML] ROS homeostasis and metabolism: a critical liaison for cancer therapy

J Kim, J Kim, JS Bae - Experimental & molecular medicine, 2016 - nature.com
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …

Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity

CE Paulsen, TH Truong, FJ Garcia, A Homann… - Nature chemical …, 2012 - nature.com
Protein sulfenylation is a post-translational modification of emerging importance in higher
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …

Lyn is a redox sensor that mediates leukocyte wound attraction in vivo

SK Yoo, TW Starnes, Q Deng, A Huttenlocher - Nature, 2011 - nature.com
Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type
of 'unhealed wound'—generate hydrogen peroxide (H2O2) through an NADPH oxidase …

Redox regulation of protein kinases

A Corcoran, TG Cotter - The FEBS journal, 2013 - Wiley Online Library
Reactive oxygen species (ROS) have been long regarded as by‐products of a cascade of
reactions stemming from cellular oxygen metabolism, which, if they accumulate to toxic …

Orchestrating redox signaling networks through regulatory cysteine switches

CE Paulsen, KS Carroll - ACS chemical biology, 2010 - ACS Publications
Hydrogen peroxide (H2O2) acts as a second messenger that can mediate intracellular
signal transduction via chemoselective oxidation of cysteine residues in signaling proteins …

The role of Src kinase in macrophage‐mediated inflammatory responses

SE Byeon, YS Yi, J Oh, BC Yoo, S Hong… - Mediators of …, 2012 - Wiley Online Library
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and
proliferation. Many studies have shown that Src plays multiple roles in macrophage …