[HTML][HTML] Cysteine-mediated redox signaling: chemistry, biology, and tools for discovery
CE Paulsen, KS Carroll - Chemical reviews, 2013 - ACS Publications
Reactive oxygen, nitrogen, and sulfur species, referred to as ROS, RNS, and RSS,
respectively, are produced during normal cell function and in response to various stimuli. An …
respectively, are produced during normal cell function and in response to various stimuli. An …
Targeting antioxidants for cancer therapy
A Glasauer, NS Chandel - Biochemical pharmacology, 2014 - Elsevier
Cancer cells are characterized by an increase in the rate of reactive oxygen species (ROS)
production and an altered redox environment compared to normal cells. Furthermore, redox …
production and an altered redox environment compared to normal cells. Furthermore, redox …
[HTML][HTML] Src: coordinating metabolism in cancer
SG Pelaz, A Tabernero - Oncogene, 2022 - nature.com
Metabolism must be tightly regulated to fulfil the dynamic requirements of cancer cells during
proliferation, migration, stemness and differentiation. Src is a node of several signals …
proliferation, migration, stemness and differentiation. Src is a node of several signals …
[HTML][HTML] Signaling pathways in vascular function and hypertension: molecular mechanisms and therapeutic interventions
J Ma, Y Li, X Yang, K Liu, X Zhang, X Zuo… - Signal transduction and …, 2023 - nature.com
Hypertension is a global public health issue and the leading cause of premature death in
humans. Despite more than a century of research, hypertension remains difficult to cure due …
humans. Despite more than a century of research, hypertension remains difficult to cure due …
[HTML][HTML] ROS homeostasis and metabolism: a critical liaison for cancer therapy
J Kim, J Kim, JS Bae - Experimental & molecular medicine, 2016 - nature.com
Evidence indicates that hypoxia and oxidative stress can control metabolic reprogramming
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …
of cancer cells and other cells in tumor microenvironments and that the reprogrammed …
Peroxide-dependent sulfenylation of the EGFR catalytic site enhances kinase activity
Protein sulfenylation is a post-translational modification of emerging importance in higher
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …
eukaryotes. However, investigation of its diverse roles remains challenging, particularly …
Lyn is a redox sensor that mediates leukocyte wound attraction in vivo
Tissue wounding induces the rapid recruitment of leukocytes. Wounds and tumours—a type
of 'unhealed wound'—generate hydrogen peroxide (H2O2) through an NADPH oxidase …
of 'unhealed wound'—generate hydrogen peroxide (H2O2) through an NADPH oxidase …
Redox regulation of protein kinases
A Corcoran, TG Cotter - The FEBS journal, 2013 - Wiley Online Library
Reactive oxygen species (ROS) have been long regarded as by‐products of a cascade of
reactions stemming from cellular oxygen metabolism, which, if they accumulate to toxic …
reactions stemming from cellular oxygen metabolism, which, if they accumulate to toxic …
Orchestrating redox signaling networks through regulatory cysteine switches
CE Paulsen, KS Carroll - ACS chemical biology, 2010 - ACS Publications
Hydrogen peroxide (H2O2) acts as a second messenger that can mediate intracellular
signal transduction via chemoselective oxidation of cysteine residues in signaling proteins …
signal transduction via chemoselective oxidation of cysteine residues in signaling proteins …
The role of Src kinase in macrophage‐mediated inflammatory responses
SE Byeon, YS Yi, J Oh, BC Yoo, S Hong… - Mediators of …, 2012 - Wiley Online Library
Src kinase (Src) is a tyrosine protein kinase that regulates cellular metabolism, survival, and
proliferation. Many studies have shown that Src plays multiple roles in macrophage …
proliferation. Many studies have shown that Src plays multiple roles in macrophage …