The evaluation of every electrocardiogram should also include an effort to interpret the QT
interval to assess the risk of malignant arrhythmias and sudden death associated with an …

This consensus guideline discusses the electrocardiographic phenomenon of beat-to-beat
QT interval variability (QTV) on surface electrocardiograms. The text covers measurement …

Cardiac repolarization abnormalities can be caused by a wide range of cardiac and non‐
cardiac compounds and may lead to the development of life‐threatening Torsades de …

Chronic heart failure is a clinical syndrome with multiple etiologies, associated with
significant morbidity and mortality. Cardiac arrhythmias, including ventricular …

The human ether-à-go-go–related gene (hERG; or KCNH2) encodes the voltage-gated
potassium channel underlying IKr, a repolarizing current in the heart. Mutations in KCNH2 or …

The high incidence of sudden cardiac death in heart failure (HF) reflects electrophysiologic
changes in response to myocardial failure. We previously showed that short-term variability …

This review aims to clarify the underlying risk of arrhythmia associated with the use of
macrolides and fluoroquinolones antibiotics. Torsades de pointes (TdP) is a rare potential …

Rationale: Spontaneous Ca2+ release (SCR) from the sarcoplasmic reticulum can cause
delayed afterdepolarizations and triggered activity, contributing to arrhythmogenesis during …

Beat-to-beat variability of repolarization duration (BVR) is an intrinsic characteristic of
cardiac function and a better marker of proarrhythmia than repolarization prolongation …

Pharmacological safety evaluation of (pro) drugs includes cardiac safety assessment of
proarrhythmic liability in healthy tissue with emphasis on the rapid component of the delayed …