Antiphospholipid syndrome: advances in diagnosis, pathogenesis, and management

JS Knight, DW Branch, TL Ortel - bmj, 2023 - bmj.com
Antiphospholipid syndrome (APS) is a thrombo-inflammatory disease propelled by
circulating autoantibodies that recognize cell surface phospholipids and phospholipid …

Animal models of cardiovascular complications of pregnancy

Z Arany, D Hilfiker-Kleiner, SA Karumanchi - Circulation research, 2022 - Am Heart Assoc
Cardiovascular complications of pregnancy have risen substantially over the past decades,
and now account for the majority of pregnancy-induced maternal deaths, as well as having …

Variable Cre Recombination Efficiency in Placentas of Cyp19-Cre ROSAmT/mG Transgenic Mice

P Anamthathmakula, PD Shallie, N Nayak, S Dhal… - Cells, 2023 - mdpi.com
The aromatase-Cre recombinase (Cyp19-Cre) transgenic mouse model has been
extensively used for placenta-specific gene inactivation. In a pilot study, we observed …

Exosomal miR-146a-5p derived from human umbilical cord mesenchymal stem cells can alleviate antiphospholipid antibody-induced trophoblast injury and placental …

Q Lv, Y Wang, W Tian, Y Liu, M Gu, X Jiang… - Journal of …, 2023 - Springer
Exosomes originating from human umbilical cord mesenchymal stem cells (hucMSC-exos)
have become a novel strategy for treating various diseases owing to their ability to regulate …

Pregnancy in antiphospholipid syndrome: what should a rheumatologist know?

L Andreoli, F Regola, A Caproli, F Crisafulli… - …, 2024 - academic.oup.com
This review focuses on the management of reproductive issues in women who have
antiphospholipid syndrome (APS) or are carriers of antiphospholipid antibodies (aPL). The …

Differences in endothelial activation and dysfunction induced by antiphospholipid antibodies among groups of patients with thrombotic, refractory, and non-refractory …

M Velásquez, LF Peláez, M Rojas… - Frontiers in …, 2021 - frontiersin.org
Antiphospholipid syndrome (APS) is an autoimmune disorder characterized by pregnancy
morbidity or thrombosis and persistent antiphospholipid antibodies (aPL) that bind to the …

Trophoblast cell function in the antiphospholipid syndrome

S Vrzić Petronijević, A Vilotić, Ž Bojić-Trbojević… - Biomedicines, 2023 - mdpi.com
Antiphospholipid syndrome (APS) is a complex thrombo-inflammatory autoimmune disease
characterized by the presence of antiphospholipid antibodies (aPL). Women with APS are at …

Lipid-binding antiphospholipid antibodies: significance for pathophysiology and diagnosis of the antiphospholipid syndrome

N Müller-Calleja, W Ruf, KJ Lackner - Critical Reviews in Clinical …, 2024 - Taylor & Francis
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the
presence of pathogenic antiphospholipid antibodies (aPL). Since approximately 30 years …

The pathogenesis of obstetric APS: a 2023 update

C Mineo, PW Shaul, BL Bermas - Clinical Immunology, 2023 - Elsevier
The antiphospholipid syndrome (APS) is an autoimmune disease characterized by the
persistent presence of antibodies directed against phospholipids and phospholipid-binding …

Transcriptomics analysis of differential gene expression and immune and inflammatory response mechanisms in patients with typical and non-criteria obstetric …

X Qi, P Liu, Y Zhou, L Lei, G Xue, R Wang… - Journal of Reproductive …, 2024 - Elsevier
In this study, we investigated the molecular differences between patients with typical
obstetric antiphospholipid syndrome (OAPS) and patients with non-criteria obstetric …