Given that hypoxia is a persistent physiological feature of many different solid tumors and a
key driver for cancer malignancy, it is thought to be a major target in cancer treatment …

Conventional chemotherapy, one of the most widely used cancer treatment methods, has
serious side effects, and usually results in cancer treatment failure. Drug resistance is one of …

For more accurate diagnosis and effective treatment of cancer, we proposed to develop a
hetero-multinuclear metal complex based on the property of apoferritin (AFt) for targeting …

Tumor-associated macrophages (TAMs) are important immune cells in the tumor
microenvironment (TME). Previous studies have shown that TAMs play a dual role in the …

Introduction Cancer development and progression is a complex process influenced by co-
evolution of the cancer cells and their microenvironment. However, traditional anti-cancer …

Tumor‑associated macrophages (TAMs) are crucial cells of the tumor microenvironment
(TME), which belong to the innate immune system and regulate primary tumor growth …

The tumor microenvironment (TME) is a critical determinant in the initiation, progression, and
treatment outcomes of various cancers. Comprising of cancer‐associated fibroblasts (CAF) …

Abstract Arachidonic acid 5-lipoxygenase (5-LOX), an enzyme that synthesizes leukotrienes
(LTs), is involved in cancer development including proliferation, invasion, metastasis and …

Background The clinical observation showed a potential additive effect of anti-PD-1 agents
and cetirizine in patients with advanced melanoma. Methods Clinical outcomes of …

Objective This systematic review aims to evaluate existing evidence to investigate the
therapeutic efficacy of M2 macrophage-derived exosomes in bone regeneration. Design A …