New approaches and challenges to targeting the endocannabinoid system
V Di Marzo - Nature Reviews Drug Discovery, 2018 - nature.com
The endocannabinoid signalling system was discovered because receptors in this system
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
are the targets of compounds present in psychotropic preparations of Cannabis sativa. The …
Paracetamol–An old drug with new mechanisms of action
GW Przybyła, KA Szychowski… - Clinical and Experimental …, 2021 - Wiley Online Library
Paracetamol (acetaminophen) is the most commonly used over‐the‐counter (OTC) drug in
the world. Despite its popularity and use for many years, the safety of its application and its …
the world. Despite its popularity and use for many years, the safety of its application and its …
[HTML][HTML] Rescuing over-activated microglia restores cognitive performance in juvenile animals of the Dp (16) mouse model of Down syndrome
Microglia are brain-resident immune cells and regulate mechanisms essential for cognitive
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …
functions. Down syndrome (DS), the most frequent cause of genetic intellectual disability, is …
Paracetamol (acetaminophen): A familiar drug with an unexplained mechanism of action
SS Ayoub - Temperature, 2021 - Taylor & Francis
Paracetamol (acetaminophen) is undoubtedly one of the most widely used drugs worldwide.
As an over-the-counter medication, paracetamol is the standard and first-line treatment for …
As an over-the-counter medication, paracetamol is the standard and first-line treatment for …
A guide to targeting the endocannabinoid system in drug design
A Stasiulewicz, K Znajdek, M Grudzień… - International journal of …, 2020 - mdpi.com
The endocannabinoid system (ECS) is one of the most crucial systems in the human
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …
organism, exhibiting multi-purpose regulatory character. It is engaged in a vast array of …
An updated review on the metabolite (AM404)-mediated central mechanism of action of paracetamol (acetaminophen): experimental evidence and potential clinical …
C Mallet, J Desmeules, R Pegahi… - Journal of Pain …, 2023 - Taylor & Francis
Paracetamol remains the recommended first-line option for mild-to-moderate acute pain in
general population and particularly in vulnerable populations. Despite its wide use, debate …
general population and particularly in vulnerable populations. Despite its wide use, debate …
Paracetamol (acetaminophen) and the developing brain
Paracetamol is commonly used to treat fever and pain in pregnant women, but there are
growing concerns that this may cause attention deficit hyperactivity disorder and autism …
growing concerns that this may cause attention deficit hyperactivity disorder and autism …
Cannabis and autoimmunity: possible mechanisms of action
V Giorgi, D Marotto, A Batticciotto, F Atzeni… - ImmunoTargets and …, 2021 - Taylor & Francis
Medical cannabis (MC) describes the usually inhaled or ingested use of a cannabis plant or
cannabis extract for medicinal purposes. The action of whole cannabis plants is extremely …
cannabis extract for medicinal purposes. The action of whole cannabis plants is extremely …
Cannabinoid interventions for PTSD: Where to next?
Cannabinoids are a promising method for pharmacological treatment of post-traumatic
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …
stress disorder (PTSD). Despite considerable research devoted to the effect of cannabinoid …
Gestational paracetamol exposure induces core behaviors of neurodevelopmental disorders in infant rats and modifies response to a cannabinoid agonist in females
RM Klein, VN Motomura, JD Debiasi… - Neurotoxicology and …, 2023 - Elsevier
Paracetamol (PAR) is an over-the-counter analgesic/antipyretic used during pregnancy
worldwide. Epidemiological studies have been associating gestational PAR exposure with …
worldwide. Epidemiological studies have been associating gestational PAR exposure with …