Here we tell the story of ivermectin, describing its anthelmintic and insecticidal actions and
recent studies that have sought to reposition ivermectin for the treatment of other diseases …

Nuclear receptors (NRs) represent attractive targets for the treatment of metabolic syndrome-
related diseases. In addition, natural products are an interesting pool of potential ligands …

We present the performance of HADDOCK, our information-driven docking software, in the
second edition of the D3R Grand Challenge. In this blind experiment, participants were …

Farnesoid X receptor (FXR) has important roles in maintaining bile acid and cholesterol
homeostasis. Here we report that the antiparasitic drug ivermectin is a ligand for nuclear …

Ivermectin (IVM) is an antiparasitic drug that is used worldwide and rescues hundreds of
millions of people from onchocerciasis and lymphatic filariasis. It was discovered by Satoshi …

Farnesoid X receptor (FXR) is an important regulator of bile acid, lipid, amino acid, and
glucose homeostasis, hepatic inflammation, regeneration, and fibrosis. FXR has been …

Specific bile acids and their signaling pathways play important roles in control of
(cholesterol) metabolism. Deeper insight into the interactions between endogenous (ie, bile …

The farnesoid X receptor (FXR) is a ligand-activated transcription factor belonging to the
nuclear receptor (NR) superfamily. FXR plays an important role in positively regulating …

Enterohepatic circulation is responsible for the capture of bile acids and other steroids
produced or metabolized in the liver and secreted to the intestine, for reabsorption back into …

The Farnesoid X Receptor (FXR) was recently validated in clinical studies using the bile acid
analogue Obeticholic Acid (OCA) as an attractive drug target for liver diseases such as …