Recent advances in peptide-based therapeutic strategies for breast cancer treatment
Breast cancer is the leading cause of cancer-related fatalities in female worldwide. Effective
therapies with low side effects for breast cancer treatment and prevention are, accordingly …
therapies with low side effects for breast cancer treatment and prevention are, accordingly …
Cell surface GRP94 as a novel emerging therapeutic target for monoclonal antibody cancer therapy
JW Kim, YB Cho, S Lee - Cells, 2021 - mdpi.com
Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …
Mechanisms that increase stability of estrogen receptor alpha in breast cancer
AC Tecalco-Cruz, JO Ramírez-Jarquín - Clinical breast cancer, 2017 - Elsevier
Estrogen receptor alpha (ER) is a transcriptional regulator that controls the expression of
genes related to cellular proliferation and differentiation in normal mammary tissue …
genes related to cellular proliferation and differentiation in normal mammary tissue …
Targeted-delivery of siRNA via a polypeptide-modified liposome for the treatment of gp96 over-expressed breast cancer
Z Liang, L Du, E Zhang, Y Zhao, W Wang, P Ma… - Materials Science and …, 2021 - Elsevier
Targeted gene therapy has led to significant breakthroughs in cancer treatment. Heat shock
protein gp96 is an emerging target for tumor treatment because of its transfer ability from …
protein gp96 is an emerging target for tumor treatment because of its transfer ability from …
Progress in the understanding of Estrogen Receptor Alpha Signaling in Triple-negative Breast Cancer: reactivation of silenced ER-α and signaling through ER-α36
AY Al-Kabariti, MA Abbas - Molecular Cancer Research, 2023 - AACR
Triple-negative breast cancer (TNBC) is an aggressive tumor that accounts for
approximately 15% of total breast cancer cases. It is characterized by poor prognosis and …
approximately 15% of total breast cancer cases. It is characterized by poor prognosis and …
Cellular gp96 upregulates AFP expression by blocking NR5A2 SUMOylation and ubiquitination in hepatocellular carcinoma
L Qian, Z Liang, Z Wang, J Wang, X Li… - Journal of molecular …, 2023 - academic.oup.com
Alpha-fetoprotein (AFP) is the most widely used biomarker for the diagnosis of
hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients have …
hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients have …
ERa-36 instead of ERa mediates the stimulatory effects of estrogen on the expression of viral oncogenes HPV E6/E7 and the malignant phenotypes in cervical cancer …
X Zhang, A Zhang, X Zhang, S Hu, Z Bao, Y Zhang… - Virus research, 2021 - Elsevier
High risk human papillomavirus (HPV) is the main causative factor of cervical cancer. In
addition, estrogen and its receptors are also involved in the development of carcinogenesis …
addition, estrogen and its receptors are also involved in the development of carcinogenesis …
Concomitant high expression of ERα36, GRP78 and GRP94 is associated with aggressive papillary thyroid cancer behavior
YJ Dai, YB Qiu, R Jiang, M Xu, LY Liao, GG Chen… - Cellular Oncology, 2018 - Springer
Purpose Papillary thyroid cancer (PTC) is more common in women than in men. It has been
suggested that estrogen may be involved in its development, as has previously been shown …
suggested that estrogen may be involved in its development, as has previously been shown …
[HTML][HTML] GRP78 positively regulates estrogen‑stimulated cell growth mediated by ER‑α36 in gastric cancer cells
Z Fu, X Wang, H Zhou, Y Li… - Molecular …, 2017 - spandidos-publications.com
Abstract Estrogen receptor (ER)‑α36, a novel isoform of ER, primarily mediates non‑classical
estrogen signaling. It has been reported that ER‑α36‑mediated growth stimulating signals …
estrogen signaling. It has been reported that ER‑α36‑mediated growth stimulating signals …
[HTML][HTML] PEG 修饰有效提高热休克蛋白gp96 抑制性多肽抗乳腺癌的功能
刘璐璐, 高建伟, 李长菲, 武岳, 孟颂东 - 生物工程学报, 2022 - cjb.ijournals.cn
乳腺癌是女性恶性肿瘤中发病率最高的肿瘤, 严重威胁女性生命健康. 其中三阴性乳腺癌因其
特殊的生理学特点, 成为乳腺癌中预后最差的亚型, 因此急需寻找新的靶点进行治疗来提高患者 …
特殊的生理学特点, 成为乳腺癌中预后最差的亚型, 因此急需寻找新的靶点进行治疗来提高患者 …