Breast cancer is the leading cause of cancer-related fatalities in female worldwide. Effective
therapies with low side effects for breast cancer treatment and prevention are, accordingly …

Glucose-regulated protein 94 (GRP94) is an endoplasmic reticulum (ER)-resident member
of the heat shock protein 90 (HSP90) family. In physiological conditions, it plays a vital role …

Estrogen receptor alpha (ER) is a transcriptional regulator that controls the expression of
genes related to cellular proliferation and differentiation in normal mammary tissue …

Targeted gene therapy has led to significant breakthroughs in cancer treatment. Heat shock
protein gp96 is an emerging target for tumor treatment because of its transfer ability from …

Triple-negative breast cancer (TNBC) is an aggressive tumor that accounts for
approximately 15% of total breast cancer cases. It is characterized by poor prognosis and …

Alpha-fetoprotein (AFP) is the most widely used biomarker for the diagnosis of
hepatocellular carcinoma (HCC). However, a substantial proportion of HCC patients have …

High risk human papillomavirus (HPV) is the main causative factor of cervical cancer. In
addition, estrogen and its receptors are also involved in the development of carcinogenesis …

Purpose Papillary thyroid cancer (PTC) is more common in women than in men. It has been
suggested that estrogen may be involved in its development, as has previously been shown …

Abstract Estrogen receptor (ER)‑α36, a novel isoform of ER, primarily mediates non‑classical
estrogen signaling. It has been reported that ER‑α36‑mediated growth stimulating signals …

乳腺癌是女性恶性肿瘤中发病率最高的肿瘤, 严重威胁女性生命健康. 其中三阴性乳腺癌因其
特殊的生理学特点, 成为乳腺癌中预后最差的亚型, 因此急需寻找新的靶点进行治疗来提高患者 …