Fighting against skin aging: the way from bench to bedside
S Zhang, E Duan - Cell transplantation, 2018 - journals.sagepub.com
As the most voluminous organ of the body that is exposed to the outer environment, the skin
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …
suffers from both intrinsic and extrinsic aging factors. Skin aging is characterized by features …
Protein lipidation: occurrence, mechanisms, biological functions, and enabling technologies
Protein lipidation, including cysteine prenylation, N-terminal glycine myristoylation, cysteine
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
palmitoylation, and serine and lysine fatty acylation, occurs in many proteins in eukaryotic …
[HTML][HTML] Epigenetic clock for skin and blood cells applied to Hutchinson Gilford Progeria Syndrome and ex vivo studies
DNA methylation (DNAm)-based biomarkers of aging have been developed for many
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
tissues and organs. However, these biomarkers have sub-optimal accuracy in fibroblasts …
Association of lonafarnib treatment vs no treatment with mortality rate in patients with Hutchinson-Gilford progeria syndrome
LB Gordon, H Shappell, J Massaro, RB D'Agostino… - Jama, 2018 - jamanetwork.com
Importance Hutchinson-Gilford progeria syndrome (HGPS) is an extremely rare fatal
premature aging disease. There is no approved treatment. Objective To evaluate the …
premature aging disease. There is no approved treatment. Objective To evaluate the …
Telomerase therapy reverses vascular senescence and extends lifespan in progeria mice
Abstract Aims Hutchinson-Gilford progeria syndrome (HGPS) is an accelerated ageing
syndrome associated with premature vascular disease and death due to heart attack and …
syndrome associated with premature vascular disease and death due to heart attack and …
Molecular and cellular bases of lipodystrophy syndromes
J Zammouri, C Vatier, E Capel, M Auclair… - Frontiers in …, 2022 - frontiersin.org
Lipodystrophy syndromes are rare diseases originating from a generalized or partial loss of
adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired …
adipose tissue. Adipose tissue dysfunction results from heterogeneous genetic or acquired …
Isoprenoids and protein prenylation: implications in the pathogenesis and therapeutic intervention of Alzheimer's disease
The mevalonate–isoprenoid–cholesterol biosynthesis pathway plays a key role in human
health and disease. The importance of this pathway is underscored by the discovery that two …
health and disease. The importance of this pathway is underscored by the discovery that two …
Vascular smooth muscle–specific progerin expression accelerates atherosclerosis and death in a mouse model of Hutchinson-Gilford progeria syndrome
MR Hamczyk, R Villa-Bellosta, P Gonzalo… - Circulation, 2018 - Am Heart Assoc
Background: Progerin, an aberrant protein that accumulates with age, causes the rare
genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS …
genetic disease Hutchinson-Gilford progeria syndrome (HGPS). Patients who have HGPS …
[PDF][PDF] A cell-intrinsic interferon-like response links replication stress to cellular aging caused by progerin
R Kreienkamp, S Graziano, N Coll-Bonfill… - Cell reports, 2018 - cell.com
Hutchinson-Gilford progeria syndrome (HGPS) is a premature aging disease caused by a
truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS …
truncated lamin A protein (progerin) that drives cellular and organismal decline. HGPS …
Hutchinson–Gilford progeria syndrome: a premature aging disease
Progeria is sporadic, very rare, autosomal dominant, deadly childhood disorder. It is one of
the progeroid syndromes also known as Hutchinson–Gilford progeria syndrome (HGPS) …
the progeroid syndromes also known as Hutchinson–Gilford progeria syndrome (HGPS) …