Atherosclerosis is the major cause of the development of cardiovascular disease, which, in
turn, is one of the leading causes of mortality worldwide. From the point of view of …

The B cell receptor (BCR) initiates immune responses through antigen recognition. We
report a 3.3-angstrom cryo–electron microscopy structure of human immunoglobulin M (IgM) …

Simple Summary Dysregulated B-cell receptor (BCR) signaling is considered a potent
contributor to tumor survival in different subtypes of B-cell non-Hodgkin lymphomas (B …

Loss-of-function mutations in NFKBIE, which encodes for the NF-κB inhibitor IκBε, are
frequent in chronic lymphocytic leukemia (CLL) and certain other B-cell malignancies and …

Anti-cancer immunotherapy, which includes cellular immunotherapy, immune checkpoint
inhibitors and cancer vaccines, has transformed the treatment strategies of several …

The clinical introduction of the Bruton's tyrosine kinase (BTK) inhibitor ibrutinib, which targets
B-cell antigen-receptor (BCR)-controlled integrin-mediated retention of malignant B cells in …

Upon antigen binding, the B cell receptor (BCR) undergoes clustering to form a signalosome
that propagates downstream signaling required for normal B cell development and …

Simple Summary Since the identification of a large variety of biomarkers in B cell
malignancies as being driving factors for tumor progression and patient prognosis, their …

Uncontrolled chronic inflammation, in most cases due to excessive cytokine signaling
through their receptors, is known to contribute to the development of tumorigenesis …

Germinal center is a transient lymphoid tissue structure in which B cells undergo affinity
maturation and differentiate into memory B cells and plasma cells. GC formation depends on …