The microbiome shapes many host traits, yet the biology of microbiomes challenges
traditional evolutionary models. Here, we illustrate how integrating the microbiome into …

Synthetic biology applies genetic tools to engineer living cells and organisms analogous to
the programming of machines. In materials synthetic biology, engineering principles from …

Abstract Development of central nervous system (CNS) is regulated by both intrinsic and
peripheral signals. Previous studies have suggested that environmental factors affect …

Although the impact of host genetics on gut microbial diversity and the abundance of specific
taxa is well established,,,,–, little is known about how host genetics regulates the genetic …

What enables strains of the same species to coexist in a microbiome? Here, we investigate
whether host anatomy can explain strain co-residence of Cutibacterium acnes, the most …

Neurodegenerative diseases are characterized by the progressive functional loss of
neurons in the brain, causing cognitive impairment and motoneuron disability. Although …

Carotenoids have been related to a number of health benefits. Their dietary intake and
circulating levels have been associated with a reduced incidence of obesity, diabetes …

Glioblastoma multiforme (GBM) is the most malignant intracranial tumor in adults,
characterized by extensive infiltrative growth, high vascularization, and resistance to multiple …

The human gut microbiota resides within a diverse chemical environment challenging our
ability to understand the forces shaping this ecosystem. Here, we reveal that fitness of the …

The genetic composition of the gut microbiota is constantly reshaped by ecological and
evolutionary forces. These strain-level dynamics are challenging to understand because …