Oxidative stress, inflammation, mitochondrial dysfunction, reduced protein synthesis, and
increased proteolysis are all critical factors in the process of muscle atrophy. In particular …

Space colonization represents the most insidious challenge for mankind, as numerous
obstacles affect the success of space missions. Specifically, the absence of gravitational …

Skeletal muscle atrophy is a common and debilitating condition that lacks an effective
therapy. Oxidative stress and inflammation are two main molecular mechanisms involved in …

Novel treatments for muscle wasting are of significant value to patients with disease states
that result in muscle weakness, injury recovery after immobilization and bed rest, and for …

Insufficient stress response and elevated oxidative stress can contribute to skeletal muscle
atrophy during mechanical unloading (eg, spaceflight and bedrest). Perturbations in heat …

Skeletal muscles overcome terrestrial, gravitational loading by producing tensile forces that
produce movement through joint rotation. Conversely, the microgravity of spaceflight …

Skeletal muscle disuse leads to pathological muscle activity as well as to slow-to-fast fiber-
type transformation. Fast-type fibers are more fatigable than slow-type, so this transformation …

Extended bed rest or limb immobilization can significantly reduce skeletal muscle mass and
function. Recovery may be incomplete, particularly in older adults. Our laboratory recently …

Background Unloading/disuse induces skeletal muscle atrophy in bedridden patients and
aged people, who cannot prevent it by means of exercise. Because interventions against …

Sesamol is a major bioactive component extracted from sesame seeds and has various
medicinal properties. However, the effects of sesamol on sarcopenia associated with aging …