Decades of research in skeletal muscle physiology have provided multiscale insights into
the structural and functional complexity of this important anatomical tissue, designed to …

Cancer stem cells (CSCs) possess the capacity to self-renew and to generate
heterogeneous lineages of cancer cells that comprise tumors. A substantial body of …

We report the results of whole-genome and transcriptome sequencing of tumor and adjacent
normal tissue samples from 17 patients with non-small cell lung carcinoma (NSCLC). We …

Genome-wide association studies (GWAS) for kidney function identified hundreds of risk
regions; however, the causal variants, target genes, cell types, and disease mechanisms …

The satellite cell of skeletal muscle provides a paradigm for quiescent and activated tissue
stem cell states. We have carried out transcriptome analyses on satellite cells purified by …

Ability to form cellular aggregations such as tumorspheres and spheroids have been used
as a morphological marker of malignant cancer cells and in particular cancer stem cells …

There are several definitions of biomarkers. A biomarker is a characteristic that can be
objectively measured and evaluated as an indicator of a physiological as well as a …

Background Circulating cell-free DNA (cfDNA) has recently been recognized as a resource
for biomarkers of cancer progression, treatment response, and drug resistance. However …

The serine threonine kinase Akt1 has been implicated in the control of cellular metabolism,
survival and growth. Here, disruption of the ubiquitously expressed member of the Akt family …

Abstract The Eyes Absent (EYA) proteins, first described in the context of fly eye
development, are now implicated in processes as disparate as organ development, innate …