Persistent inward currents in motoneuron dendrites: implications for motor output

CJ Heckman, MA Gorassini… - Muscle & Nerve: Official …, 2005 - Wiley Online Library
The dendrites of motoneurons are not, as once thought, passive conduits for synaptic inputs.
Instead they have voltage‐dependent channels that provide the capacity to generate a very …

Motoneuron excitability: the importance of neuromodulatory inputs

CJ Heckman, C Mottram, K Quinlan, R Theiss… - Clinical …, 2009 - Elsevier
The excitability of spinal motoneurons is both fundamental for motor behavior and essential
in diagnosis of neural disorders. There are two mechanisms for altering this excitability. The …

Persistent inward currents in spinal motoneurons: important for normal function but potentially harmful after spinal cord injury and in amyotrophic lateral sclerosis

SM ElBasiouny, JE Schuster, CJ Heckman - Clinical neurophysiology, 2010 - Elsevier
Meaningful body movements depend on the interplay between synaptic inputs to
motoneurons and their intrinsic properties. Injury and disease often alter either or both of …

Methods to quantify pharmacologically induced alterations in motor function in human incomplete SCI

CK Thompson, A Jayaraman, C Kinnaird… - JoVE (Journal of …, 2011 - jove.com
Spinal cord injury (SCI) is a debilitating disorder, which produces profound deficits in
volitional motor control. Following medical stabilization, recovery from SCI typically involves …

Identification of Somatosensory Pathways by Focal-Cooling-Induced Changes of Somatosensory Evoked Potentials and EEG-Activity–an Experimental Study

K Schwerdtfeger, S Von Tiling, M Kiefer, M Strowitzki… - Acta …, 1999 - Springer
Object. Function-preserving neurosurgery requires methods to identify functionally important
CNS-areas intraoperatively. We investigated whether a combination of focal cerebro-cortical …

Enhancement and depression of spinal reflexes by 8‐hydroxy‐2‐(di‐n‐propylamino) tetralin in the decerebrated and spinalized rabbit: involvement of 5‐HT1A‐and …

RW Clarke, J Ogilvie… - British journal of …, 1997 - Wiley Online Library
1 In decerebrated, spinalized and paralyzed rabbits, intravenous administration of the 5‐
HT1A‐receptor agonists (±)‐8‐hydroxy‐2‐(di‐n‐propylamino) tetralin (8‐OH‐DPAT, 3–300 …

On the role of 5‐HT1B/1D receptors in modulating transmission in a spinal reflex pathway in the decerebrated rabbit

J Ogilvie, M Wigglesworth, L Appleby… - British journal of …, 1999 - Wiley Online Library
In decerebrated rabbits, the selective 5‐HT1B/1D receptor antagonist GR 127,935 had no
significant effects on reflexes evoked in medial gastrocnemius motoneurones by electrical …

Serotonergic Modulation of Spinal Circuitry Restores Motor Function after Chronic Spinal Cord Injury

S Walvekar, RB Robinson, HM Chadwick, RM Burch… - bioRxiv, 2022 - biorxiv.org
Electrical stimulation of the nervous system, in conjunction with use-dependent
rehabilitation, has been employed for treatment of paralysis following spinal cord injury …

[图书][B] The dominant role of the hip in multijoint reflex responses in human spinal cord injury

T Onushko - 2011 - search.proquest.com
Following a spinal cord injury (SCI), people often experience exaggerated reflexes, such
that mild provocations can cause prolonged and uncontrolled muscle activity throughout the …

Monoaminergic modulation of physiological responsiveness, intrinsic input-output functioning and persistent inward currents of mammalian ventral horn interneurons

RD Theiss - 2005 - search.proquest.com
Spinal interneurons are essential integrators of synaptic transmission for motor control,
receiving abundant descending input from the brain and brainstem as well as afferent …