The structure and integrity of telomeres are essential for genome stability. Telomere
dysregulation can lead to cell death, cell senescence, or abnormal cell proliferation. The …

Telomerase is the enzyme responsible for maintenance of the length of telomeres by
addition of guanine-rich repetitive sequences. Telomerase activity is exhibited in gametes …

Background Mutations in TERC, the gene for the RNA component of telomerase, cause
short telomeres in congenital aplastic anemia and in some cases of apparently acquired …

Telomeres, the physical ends of eukaryotes chromosomes are transcribed into telomeric
repeat containing RNA (TERRA), a large non-coding RNA of unknown function, which forms …

Human telomerase contains a 451 nt RNA (hTR) and several proteins, including a
specialized reverse transcriptase (hTERT). The 5′ half of hTR comprises the pseudoknot …

Abstract The Nobel Prize in Physiology or Medicine was recently awarded to Elizabeth
Blackburn, Carol Greider and Jack Szostak for their pioneering studies on chromosome …

In bacteria, numerous genes harbor regulatory elements in the 5′ untranslated regions of
their mRNA, termed riboswitches, which control gene expression by binding small-molecule …

Telomerase is a specialized DNA polymerase that extends the 3′ ends of eukaryotic linear
chromosomes, a process required for genomic stability and cell viability. Here we present …

Maintenance of telomeres by the enzyme telomerase is essential for genomic stability and
cell viability in ciliates, vertebrates and yeast. The minimal components of telomerase …

Telomerase is a reverse transcriptase specialized in the addition of telomeric DNA repeats
onto the ends of chromosomes. Telomere extension offsets the loss of telomeric repeats …