Vagus nerve stimulation in brain diseases: Therapeutic applications and biological mechanisms

Y Wang, G Zhan, Z Cai, B Jiao, Y Zhao, S Li… - … & Biobehavioral Reviews, 2021 - Elsevier
Brain diseases, including neurodegenerative, cerebrovascular and neuropsychiatric
diseases, have posed a deleterious threat to human health and brought a great burden to …

Vagus nerve and vagus nerve stimulation, a comprehensive review: part II

H Yuan, SD Silberstein - Headache: The Journal of Head and …, 2016 - Wiley Online Library
The development of vagus nerve stimulation (VNS) began in the 19th century. Although it
did not work well initially, it introduced the idea that led to many VNS‐related animal studies …

Nine-year prospective efficacy and safety of brain-responsive neurostimulation for focal epilepsy

DR Nair, KD Laxer, PB Weber, AM Murro, YD Park… - Neurology, 2020 - AAN Enterprises
Objective To prospectively evaluate safety and efficacy of brain-responsive neurostimulation
in adults with medically intractable focal onset seizures (FOS) over 9 years. Methods Adults …

Non-invasive access to the vagus nerve central projections via electrical stimulation of the external ear: fMRI evidence in humans

E Frangos, J Ellrich, BR Komisaruk - Brain stimulation, 2015 - Elsevier
Background Tract-tracing studies in cats and rats demonstrated that the auricular branch of
the vagus nerve (ABVN) projects to the nucleus tractus solitarii (NTS); it has remained …

Long-term treatment with responsive brain stimulation in adults with refractory partial seizures

GK Bergey, MJ Morrell, EM Mizrahi, A Goldman… - Neurology, 2015 - AAN Enterprises
Objective: The long-term efficacy and safety of responsive direct neurostimulation was
assessed in adults with medically refractory partial onset seizures. Methods: All participants …

Two‐year seizure reduction in adults with medically intractable partial onset epilepsy treated with responsive neurostimulation: final results of the RNS System Pivotal …

CN Heck, D King‐Stephens, AD Massey, DR Nair… - …, 2014 - Wiley Online Library
Objective To demonstrate the safety and effectiveness of responsive stimulation at the
seizure focus as an adjunctive therapy to reduce the frequency of seizures in adults with …

Chronic vagal stimulation for the treatment of low ejection fraction heart failure: results of the NEural Cardiac TherApy foR Heart Failure (NECTAR-HF) randomized …

F Zannad, GM De Ferrari, AE Tuinenburg… - European heart …, 2015 - academic.oup.com
Aim The neural cardiac therapy for heart failure (NECTAR-HF) was a randomized sham-
controlled trial designed to evaluate whether a single dose of vagal nerve stimulation (VNS) …

Vagus nerve stimulation for the treatment of epilepsy

HFJ González, A Yengo-Kahn… - Neurosurgery …, 2019 - neurosurgery.theclinics.com
Approximately 50 million people worldwide suffer from epilepsy, and approximately 30% to
40% of these persons have seizures that are refractory to treatment with antiepileptic …

Reflex control of immunity

KJ Tracey - Nature Reviews Immunology, 2009 - nature.com
Inflammation can cause damage and even death. What controls this primitive and potentially
lethal innate immune response to injury and infection? Molecular and neurophysiological …

Application of machine learning to epileptic seizure onset detection and treatment

AH Shoeb - 2009 - dspace.mit.edu
Epilepsy is a chronic disorder of the central nervous system that predisposes individuals to
experiencing recurrent seizures. It affects 3 million Americans and 50 million people world …