Conspectus Nucleic acids contain a variety of different base modifications, such as
decoration at the fifth position of cytosine, which is one of the most important epigenetic …

An azide and hydrazine tethered to a naphthalimide analogue was created to selectively
react with 5-formyluracil in one system and fluorogenically label 5-formylcytosine in another …

Recently, the detection of natural thymine modified 5-formyluracil has attracted widespread
attention. Herein, we introduce a new insight into designing reagents for both the selective …

The chemically selective detection of natural nucleobase modifications has been regarded
as the key step in understanding their important roles in epigenetics. Herein, for the first time …

A naphthalimide hydroxylamine probe has been designed and synthesized to selectively
label the whole natural aldehydes present in DNAs including 5-formylcytosine, 5 …

hydroxymethyluracil (5hmU) is formed through oxidation of thymine both enzymatically and
non‐enzymatically in various biological systems. Although 5hmU has been reported to affect …

DNA templates containing 5-hydroxymethyluracil or 5-hydroxymethylcytosine were used in
an in vitro transcription assay with RNA polymerase from Escherichia coli. A strong …

Chemical modifications to nucleobases have a great influence on various cellular
processes, by making gene regulation more complex, thus indicating their profound impact …

Abstract In organisms 5‐formyluracil (5fU), which is known as a vital natural nucleobase, is
widely present. Despite the recent development of sensor designs for organic fluorescent …

5-Formyluracil (5fU) is considered an important epigenetic modification agent involved in
gene regulation, cell differentiation, and development. 5fU exists in many cells and tissues …