Chemoprevention strategies reduce malaria disease and death, but the efficacy of anti-
malarial drugs used for chemoprevention is perennially threatened by drug resistance. This …

Introduction Since the spread of chloroquine resistance in Plasmodium falciparum in the
1960s, recommendations have been made on how to respond to antimalarial resistance …

Malaria parasites break down host haemoglobin into peptides and amino acids in the
digestive vacuole for export to the parasite cytoplasm for growth: interrupting this process is …

A major obstacle to malaria elimination is the great capacity of the parasite and vector
populations to evolve in response to malaria control interventions. The widespread use of …

Plasmodium falciparum resistance to chloroquine, the former gold standard antimalarial
drug, is mediated primarily by mutant forms of the chloroquine resistance transporter …

The use of artemisinin-based combination therapies (ACTs), which combine an artemisinin
derivative with a partner drug, in the treatment of uncomplicated malaria has largely been …

Artemisinin-based combination therapies (ACTs) have become the mainstay for malaria
treatment in almost all malaria endemic settings. Artemisinin derivatives are highly potent …

Abstract Purpose of Review Five years have passed since the World Health Organization
released its Global Technical Strategy for Malaria (GTS). In that time, progress against …

In Tanzania, chloroquine was replaced by sulphadoxine-pyrimethamine (SP) as a first-line
for treatment of uncomplicated malaria. Due to high resistance in malaria parasites, SP …

Background Translating genomic technologies into healthcare applications for the malaria
parasite Plasmodium falciparum has been limited by the technical and logistical difficulties …