Cancer remains one of the leading causes of death worldwide. Conventional therapeutic
strategies usually offer limited specificity, resulting in severe side effects and toxicity to …

Lentiviral vectors have been developed and used in multiple gene and cell therapy
applications. One of their main advantages over other vectors is the ability to integrate the …

The liver is a key organ for metabolism, protein synthesis, detoxification, and endocrine
function, and among liver diseases, including hepatitis, cirrhosis, malignant tumors, and …

HIV-1 derived lentiviral vector is an efficient transporter for delivering desired genetic
materials into the targeted cells among many viral vectors. Genetic material transduced by …

Introduction: Cancer is considered the second leading cause of death worldwide despite the
progress made in early detection and advances in classical therapies. Advancing in the fight …

Hepatocellular carcinoma (HCC) is a major global malignancy, responsible for> 90% of
primary liver cancers. Currently available therapeutic options have poor performances due …

Conventional eukaryotic expression plasmids contain a DNA backbone that is dispensable
for the cellular expression of the transgene. In order to reduce the vector size, minicircle …

Suicide genes have been widely investigated for their utility as therapeutic agents and as
tools for in vitro negative selection strategies. Several methods for delivery of suicide genes …

During epithelial to mesenchymal transition, the ability of cancer cells to transform and
metastasize is primarily determined by N-cadherin-mediated migration and invasion. This …

Viral vectors carrying suicide genes such as diphtheria toxin, Pseudomonas exotoxin, or
barnase are very useful tools in cancer gene therapy and cell ablation research. However …