[HTML][HTML] Development and optimization of vildagliptin solid lipid nanoparticles loaded ocuserts for controlled ocular delivery: A promising approach towards treating …

MMA Elsayed, A Elsayed, MA Fouad… - International Journal of …, 2024 - Elsevier
Diabetes mellitus (DM) is the most prevalent cause of diabetic retinopathy (DRP). DRP has
been recognized for a long time as a microvascular disease. Many drugs were used to treat …

[PDF][PDF] Non-steroidal anti-inflammatory drugs for topical ophthalmic administration: contemporary trends

PT Peneva - Int J Pharm Pharm Sci, 2015 - researchgate.net
Topically applied drugs for the treatment of ocular inflammation are the most commonly used
formulations due to many reasons: they are simple to use; they can be applied often and …

Ex vivo rabbit cornea diffusion studies with a soluble insert of moxifloxacin

M Sebastián-Morelló, MA Calatayud-Pascual… - Drug delivery and …, 2018 - Springer
The objective of this research was to develop and evaluate an ocular insert for the controlled
drug delivery of moxifloxacin which could perhaps be used in the treatment of corneal …

Ex-Vivo trans-corneal and trans-scleral diffusion studies with ocular formulations of glutathione as an antioxidant treatment for ocular diseases

M Sebastián-Morelló, AM Alambiaga-Caravaca… - Pharmaceutics, 2020 - mdpi.com
Exposure to sunlight and contact with atmospheric oxygen makes the eye particularly
susceptible to oxidative stress, which can potentially produce cellular damage. In …

Topical ocular administration of progesterone decreases photoreceptor cell death in Retinal Degeneration Slow (rds) mice

AM Alambiaga-Caravaca, A Cantó, V Rodilla… - Pharmaceuticals, 2022 - mdpi.com
Retinitis pigmentosa (RP) is an inherited eye disorder which triggers a cascade of retinal
disorders leading to photoreceptor cell death and for which there is currently no effective …

Preparation of Fluconazole β‐Cyclodextrin Complex Ocuserts: In Vitro and In Vivo Evaluation

H Abdul Ahad, J Sreeramulu… - International …, 2011 - Wiley Online Library
The main purpose of the present study was to develop ocuserts of Fluconazole β‐CD (beta‐
cyclodextrin) complex and to evaluate both in vitro and in vivo. Fluconazole was made …

Design, fabrication, and characterization of graft co-polymer assisted ocular insert: a state of art in reducing post-operative pain

PN Kendre, PD Kadam, SP Jain… - Drug Development …, 2020 - Taylor & Francis
Purpose Targeted delivery of drugs at appropriate concentrations to ocular tissues is
required to avoid wastage. Hence, advanced systems that maximize the release of poorly …

Preparation and In Vitro/In Vivo Evaluation of Antihistaminic Ocular Inserts

SNH Shah, A Nawaz, H Javed, M Rafiq, R Riaz… - Pharmaceutical …, 2018 - Springer
The present study aims to prepare ocular inserts of cetirizine hydrochloride, an antihistamine
used to treat allergic conjunctivitis, allergic rhinitis, uveitis and urticaria. Solvent casting …

[HTML][HTML] Contemporary trends in novel ophthalmic drug delivery system: An overview

S Naveed, S Farooq, SS Abbas, SH Jawed… - Open Access Library …, 2015 - scirp.org
One of the most challenging tasks faced by the pharmaceutical researchers is the
ophthalmic drug delivery. Their aim is to obtain and maintain a therapeutic level at the site of …

[PDF][PDF] Formulation and in vitro-in vivo correlation of timolol maleate ocular insert

S Thakral, R Issarani, BP Nagori - Indonesian Journal of …, 2015 - pdfs.semanticscholar.org
The concept of in-vitro and in-vivo correlation studies was used in pharmaceutical research
because a simple in-vitro release study on a drug product will be insufficient to predict its …