Reperfusion is mandatory to salvage ischemic myocardium from infarction, but reperfusion
per se contributes to injury and ultimate infarct size. Therefore, cardioprotection beyond that …

The function and survival of all organisms is dependent on the dynamic control of energy
metabolism, when energy demand is matched to energy supply. The AMP-activated protein …

The field of mitochondrial ion channels has recently seen substantial progress, including the
molecular identification of some of the channels. An integrative approach using genetics …

KATP channels are integral to the functions of many cells and tissues. The use of
electrophysiological methods has allowed for a detailed characterization of KATP channels …

Although metabolic conditions associated with an increased AMP/ATP ratio are primary
factors in the activation of 5′-adenosine monophosphate-activated protein kinase (AMPK) …

Understanding cellular response to environmental stress has broad implications for human
disease. AMP-activated protein kinase (AMPK) orchestrates the regulation of energy …

AMP-activated protein kinase (AMPK), a phylogenetically conserved serine/threonine
protein kinase, has been proposed to function as a 'fuel gauge'to monitor cellular energy …

A prolonged period of ischaemia followed by reperfusion irreversibly damages the heart.
Such reperfusion injury (RI) involves opening of the mitochondrial permeability transition …

The translation of successful preclinical and clinical proof-of-concept studies on
cardioprotection to the benefit of patients with reperfused acute myocardial infarction has …

Abstract Ischemia/reperfusion (I/R)-induced autophagy increases the severity of
cardiomyocyte injury. The aim of this study was to investigate the effects of berberine, a …