The role of the medial prefrontal cortex in cognition, ageing and dementia
DD Jobson, Y Hase, AN Clarkson… - Brain …, 2021 - academic.oup.com
Humans require a plethora of higher cognitive skills to perform executive functions, such as
reasoning, planning, language and social interactions, which are regulated predominantly …
reasoning, planning, language and social interactions, which are regulated predominantly …
What, if anything, is rodent prefrontal cortex?
Prefrontal cortex (PFC) means different things to different people. In recent years, there has
been a major increase in publications on the PFC, especially using mice. However …
been a major increase in publications on the PFC, especially using mice. However …
Evolution of prefrontal cortex
TM Preuss, SP Wise - Neuropsychopharmacology, 2022 - nature.com
Subdivisions of the prefrontal cortex (PFC) evolved at different times. Agranular parts of the
PFC emerged in early mammals, and rodents, primates, and other modern mammals share …
PFC emerged in early mammals, and rodents, primates, and other modern mammals share …
The neural basis of reversal learning: An updated perspective
Reversal learning paradigms are among the most widely used tests of cognitive flexibility
and have been used as assays, across species, for altered cognitive processes in a host of …
and have been used as assays, across species, for altered cognitive processes in a host of …
Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models
The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …
Emotion and motivation: the role of the amygdala, ventral striatum, and prefrontal cortex
Emotions are multifaceted, but a key aspect of emotion involves the assessment of the value
of environmental stimuli. This article reviews the many psychological representations …
of environmental stimuli. This article reviews the many psychological representations …
Linking mPFC circuit maturation to the developmental regulation of emotional memory and cognitive flexibility
CB Klune, B Jin, LA DeNardo - Elife, 2021 - elifesciences.org
The medial prefrontal cortex (mPFC) and its abundant connections with other brain regions
play key roles in memory, cognition, decision making, social behaviors, and mood …
play key roles in memory, cognition, decision making, social behaviors, and mood …
The touchscreen operant platform for testing learning and memory in rats and mice
AE Horner, CJ Heath, M Hvoslef-Eide, BA Kent… - Nature protocols, 2013 - nature.com
An increasingly popular method of assessing cognitive functions in rodents is the automated
touchscreen platform, on which a number of different cognitive tests can be run in a manner …
touchscreen platform, on which a number of different cognitive tests can be run in a manner …
Medial frontal cortex mediates perceptual attentional set shifting in the rat
JM Birrell, VJ Brown - Journal of Neuroscience, 2000 - Soc Neuroscience
If rodents do not display the behavioral complexity that is subserved in primates by prefrontal
cortex, then evolution of prefrontal cortex in the rat should be doubted. Primate prefrontal …
cortex, then evolution of prefrontal cortex in the rat should be doubted. Primate prefrontal …
Hippocampal neurogenesis: learning to remember
O Lazarov, C Hollands - Progress in neurobiology, 2016 - Elsevier
Alzheimer's disease, the most prevalent form of dementia in the elderly, is characterized by
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …
progressive memory loss and cognitive dysfunction. It has become increasingly clear that …