Klotho is a novel renoprotective anti-aging protein available in membrane-bound or soluble
form. Klotho is expressed in brain, pancreas, and other solid organs but shows highest …

S-adenosylhomocysteine (SAH) is hydrolyzed by SAH hydrolase (SAHH) to homocysteine
and adenosine. Increased plasma SAH levels were associated with disturbed renal function …

Diabetic nephropathy (DN) is the leading cause of end-stage renal disease worldwide and
is a significant burden on healthcare systems. α-klotho (klotho) is a protein known for its anti …

Background α-Klotho is a geroprotective protein that can attenuate or alleviate deleterious
changes with ageing and disease. Declines in α-Klotho play a role in the pathophysiology of …

Aims Podocyte apoptosis plays an important role in the pathogenesis of diabetic
nephropathy (DN). Astragaloside IV (AS-IV) has been shown to protect against podocyte …

Oxidative stress plays a key role in the pathogenesis of diabetic nephropathy (DN). The anti-
aging protein Klotho has been demonstrated to have antioxidant capacity. Nuclear factor …

In diabetic nephropathy (DN), glomerular endothelial cells (GECs) and podocytes undergo
pathological alterations, which are influenced by metabolic changes characteristic of …

Increased neutrophil recruitment represents a hallmark event in myocardial
ischemia/reperfusion (I/R) injury due to the ensuing inflammatory response. Circular RNAs …

Klotho, an antiaging protein, has been shown to play a protective role in renal tubular
epithelial-mesenchymal transition (EMT) during the development of diabetic kidney disease …

Klotho is an antiaging protein, and its levels decline with age and chronic stress. The
exogenous administration of Klotho can enhance cognitive performance in mice and …