The functional significance behind expressing two IL–8 receptor types on PMN
The presence of two CXCL8 receptor types combined with the inflammatory roles of PMN
has led to interest in whether each receptor type contributes to unique functions. PMN are …
has led to interest in whether each receptor type contributes to unique functions. PMN are …
[HTML][HTML] Insights from advances in research of chemically induced experimental models of human inflammatory bowel disease
M Kawada, A Arihiro, E Mizoguchi - World journal of …, 2007 - ncbi.nlm.nih.gov
Inflammatory bowel disease (IBD), the most important being Crohn's disease and ulcerative
colitis, results from chronic dysregulation of the mucosal immune system in the …
colitis, results from chronic dysregulation of the mucosal immune system in the …
Activation of aryl hydrocarbon receptor (AhR) leads to reciprocal epigenetic regulation of FoxP3 and IL-17 expression and amelioration of experimental colitis
Background Aryl hydrocarbon receptor (AhR), a transcription factor of the bHLH/PAS family,
is well characterized to regulate the biochemical and toxic effects of environmental …
is well characterized to regulate the biochemical and toxic effects of environmental …
Cxcr2 and Cxcl5 regulate the IL-17/G-CSF axis and neutrophil homeostasis in mice
J Mei, Y Liu, N Dai, C Hoffmann… - The Journal of …, 2012 - Am Soc Clin Investig
Neutrophils are essential for maintaining innate immune surveillance under normal
conditions, but also represent a major contributor to tissue damage during inflammation …
conditions, but also represent a major contributor to tissue damage during inflammation …
CXCL5 regulates chemokine scavenging and pulmonary host defense to bacterial infection
J Mei, Y Liu, N Dai, M Favara, T Greene, S Jeyaseelan… - Immunity, 2010 - cell.com
The chemokine sink hypothesis pertaining to erythrocyte Duffy Antigen Receptor for
Chemokines (DARC) during inflammation has received considerable attention, but lacks …
Chemokines (DARC) during inflammation has received considerable attention, but lacks …
Targeting the proteasome: partial inhibition of the proteasome by bortezomib or deletion of the immunosubunit LMP7 attenuates experimental colitis
N Schmidt, E Gonzalez, A Visekruna, AA Kühl… - Gut, 2010 - gut.bmj.com
Background and aims Inflammatory bowel disease (IBD), comprising Crohn´ s disease and
ulcerative colitis, is characterised by chronic relapsing inflammation of the gut. Increased …
ulcerative colitis, is characterised by chronic relapsing inflammation of the gut. Increased …
Neuronal guidance molecule netrin-1 attenuates inflammatory cell trafficking during acute experimental colitis
Background Inflammatory bowel diseases, encompassing Crohn's disease and ulcerative
colitis, are characterised by persistent leucocyte tissue infiltration leading to perpetuation of …
colitis, are characterised by persistent leucocyte tissue infiltration leading to perpetuation of …
A gut-restricted glutamate carboxypeptidase II inhibitor reduces monocytic inflammation and improves preclinical colitis
DE Peters, LD Norris, L Tenora, I Šnajdr… - Science translational …, 2023 - science.org
There is an urgent need to develop therapeutics for inflammatory bowel disease (IBD)
because up to 40% of patients with moderate-to-severe IBD are not adequately controlled …
because up to 40% of patients with moderate-to-severe IBD are not adequately controlled …
Role of chemokine receptors and intestinal epithelial cells in the mucosal inflammation and tolerance
N Kulkarni, M Pathak, G Lal - Journal of Leucocyte Biology, 2017 - academic.oup.com
The intestinal epithelial lining is a very dynamic interface, where multiple interactions occur
with the external world. The intestinal epithelial barrier is continuously exposed to a huge …
with the external world. The intestinal epithelial barrier is continuously exposed to a huge …
IL-17A and TNF-α exert synergistic effects on expression of CXCL5 by alveolar type II cells in vivo and in vitro
Y Liu, J Mei, L Gonzales, G Yang, N Dai… - The Journal of …, 2011 - journals.aai.org
CXCL5, a member of the CXC family of chemokines, contributes to neutrophil recruitment
during lung inflammation, but its regulation is poorly understood. Because the T cell-derived …
during lung inflammation, but its regulation is poorly understood. Because the T cell-derived …