Deregulation of tumor cell metabolism is widely recognized as a “hallmark of cancer.” Many
of the selective pressures encountered by tumor cells, such as exposure to anticancer …

Cancer treatment with ionizing radiation (IR) is a well-established and effective clinical
method to fight different types of tumors and is a palliative treatment to cure metastatic …

Oxidative stress and hypoxia in the retinal pigment epithelium (RPE) have long been
considered major risk factors in the pathophysiology of age-related macular degeneration …

The metabolic plasticity of mitochondria ensures cell development, differentiation, and
survival. The peptidase OMA1 regulates mitochondrial morphology via OPA1 and stress …

The enhanced expression of nitric oxide (• NO) synthase predicts triple-negative breast
cancer outcome and its resistance to different therapeutics. Our earlier work demonstrated …

Radiotherapy alters the tumor microenvironment and reprograms cellular metabolism.
Transition of tumor cell phenotypes contributes to post-radiotherapy tumor recurrence. Low …

Senescence due to exogenous and endogenous stresses triggers metabolic reprogramming
and is associated with many pathologies, including cancer. In solid tumors, senescence …

Metabolic rewiring is the result of the increasing demands and proliferation of cancer cells,
leading to changes in the biological activities and responses to treatment of cancer cells …

Hypoxia-induced radioresistance reduces the efficacy of radiotherapy for solid
malignancies, including non-small cell lung cancer (NSCLC). Cellular hypoxia can confer …

Oncogenic mutations in metabolic genes and associated oncometabolite accumulation
support cancer progression but can also restrict cellular functions needed to cope with DNA …