Two decades ago successful transfection of antigen presenting cells (APC) in vivo was
demonstrated which resulted in the induction of primary adaptive immune responses. Due to …

Cell membranes with their selective permeability play important functions in the tight control
of molecular exchanges between the cytosol and the extracellular environment as the …

Within the last decade, the introduction of checkpoint inhibitors proposed to boost the
patients' anti-tumor immune response has proven the efficacy of immunotherapeutic …

Imidazole is an azole heterocycle containing two non‐adjacent nitrogen atoms added
greatly to natural products and synthetic compounds. The planar ring system associated with …

The current therapeutic antibody market in the US consists of 100 antibody-based products
and their market value is expected to explode beyond $300 billion by 2025. These therapies …

Messenger RNA (mRNA) is a promising tool for biotherapeutics, and self-amplifying mRNA
(saRNA) is particularly advantageous, because it results in abundant protein expression and …

Lipo-oligomers have been proven as potent siRNA carriers based on stable electrostatic
and hydrophobic complex formation and endosomal membrane destabilization. Although …

Aminoglycosides are a class of naturally occurring and semi synthetic antibiotics that have
been used for a long time in fighting bacterial infections. Due to acquired antibiotic …

Cationic lipo‐oligomers containing unsaturated oleic acid are potent siRNA carriers based
on electrostatic and hydrophobic lipo‐polyplex formation and endosomal membrane …

Protein expression and RNA interference require efficient delivery of DNA or mRNA and
small double stranded RNA into cells, respectively. Although cationic lipids are the most …