The Mcm2-7 complex serves as the eukaryotic replicative helicase, the molecular motor that
both unwinds duplex DNA and powers fork progression during DNA replication. Consistent …

The nitrogen cycle (N-cycle) in the biosphere, mainly driven by prokaryotes, involves
different reductive or oxidative reactions used either for assimilatory purposes or in …

Whole-genome sequencing of the protozoan pathogen Trypanosoma cruzi revealed that the
diploid genome contains a predicted 22,570 proteins encoded by genes, of which 12,570 …

In bacteria, the initiation of replication is controlled by DnaA, a member of the ATPases
associated with various cellular activities (AAA+) protein superfamily. ATP binding allows …

Eukaryotic chromosomes possess multiple origins of replication, whereas bacterial
chromosomes are replicated from a single origin. The archaeon Pyrococcus abyssi also …

Three methods, based on DNA asymmetry, the distribution of DnaA boxes and dnaA gene
location, were applied to identify the putative replication origins in 120 chromosomes. The …

Leukotrienes are pro-inflammatory lipid mediators, which are biosynthesized via the
lipoxygenase pathway of the arachidonic acid cascade. Lipoxygenases form a family of lipid …

The homomultimeric archaeal mini-chromosome maintenance (MCM) complex serves as a
simple model for the analogous heterohexameric eukaryotic complex. Here we investigate …

Since the first archaeal genome was sequenced, much attention has been focused on the
study of these unique microorganisms. We have learnt that although archaeal DNA …

▪ Abstract Genome sequences of a number of archaea have revealed an apparent paradox
in the phylogenies of the bacteria, archaea, and eukarya, as well as an intriguing set of …