Since the discovery of group-specific component and its polymorphism by Hirschfeld in
1959, research has put spotlight on this multifunctional transport protein (vitamin D binding …

Brugada syndrome (BrS) is a primary electrical disease associated with life-threatening
arrhythmias. It is estimated to cause at least 20% of sudden cardiac deaths (SCDs) in …

The SGK1 kinase is pivotal in signal transduction pathways operating in cell transformation
and tumor progression. Here, we characterize in depth a novel potent and selective pyrazolo …

Heart diseases are common and significant contributors to worldwide mortality and
morbidity. During recent years complement mediated inflammation has been shown to be an …

Enhanced glycolysis is a hallmark of breast cancer. In cancer cells, the high glycolytic flux
induces carbonyl stress, a damaging condition in which the increase of reactive carbonyl …

Brugada syndrome (BrS) is a hereditary disorder, characterized by a specific
electrocardiogram pattern and highly related to an increased risk of sudden cardiac death …

The evolution of the current dogma surrounding Brugada syndrome (BrS) has led to a
significant debate about the real usefulness of genetic testing in this syndrome. Since BrS is …

Rapid and precise diagnostic methods are required to control emerging infectious diseases
effectively. Human body fluids are attractive clinical samples for discovering diagnostic …

Sudden cardiac death results from arrhythmias commonly caused by channelopathies and
cardiomyopathies, often due to several genetic factors. An emerging concept is that these …

Proteomic study of clinical samples aims at the better understanding of physiological and
pathological conditions, as well as the discovery of diagnostic and prognostic markers for …