Unlike the complex glycans decorating the cell surface, the O-linked β-N-acetyl glucosamine
(O-GlcNAc) modification is a simple intracellular Ser/Thr-linked monosaccharide that is …

The chromatin environment is essential for the correct specification and preservation of cell
identity through modulation and maintenance of transcription patterns. Many chromatin …

Candidate enhancers can be identified on the basis of chromatin modifications, the binding
of chromatin modifiers and transcription factors and cofactors, or chromatin accessibility …

Congenital heart disease (CHD) affects up to 1% of live births. Although a genetic etiology is
indicated by an increased recurrence risk,, sporadic occurrence suggests that CHD genetics …

To broaden our understanding of the evolution of gene regulation mechanisms, we
generated occupancy profiles for 34 orthologous transcription factors (TFs) in human …

Insulin resistance is a hallmark of diabetes and an unmet clinical need. Insulin inhibits
hepatic glucose production and promotes lipogenesis by suppressing FOXO1-dependent …

The pathophysiological function of the forkhead transcription factor FOXN3 remains to be
explored. Here we report that FOXN3 is a transcriptional repressor that is physically …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

Background: Epigenetic mechanisms are critical in the pathogenesis of pulmonary arterial
hypertension (PAH). Previous studies have suggested that hypermethylation of the BMPR2 …

Abstract The switch-independent 3 (SIN3)/histone deacetylase (HDAC) complexes play
essential roles in regulating chromatin accessibility and gene expression. There are two …