During recent years, small molecules containing five-member heterocyclic moieties have
become the subject of considerable growing interest for designing new antitumor agents …

ABSTRACT The reaction of 2, 6-dimethyl-4-phenyl-1, 4-dihydropyridine-3, 5-
dicarbohydrazide with variety of carbonyl compounds such as substituted benzaldehydes …

Background Thiazole and thiosemicarbazone derivatives are known to have potential
anticancer activity with a mechanism of action related to inhibition of matrix metallo …

A three-component reaction for the synthesis of novel 3-heteroaryl-coumarin utilizing
acetylcoumarin synthon under ultrasonic irradiation was developed using chitosan-grafted …

Background: Imidazo [2, 1-b] thiazole scaffolds were reported to possess various
pharmaceutical activities. Results: The novel compound named methyl-2-(1-(3-methyl-6-(p …

The bioisosteres of 1, 3, 4-oxadiazoles and 1, 3, 4-thiadiazoles are well-known
pharmacophores for many medicinally important drugs. Throughout the past 10 years, 1, 3, 4 …

1, 3, 4-thiadiazole is a five-membered aromatic heterocycle containing two nitrogen atoms
and one sulfur atom. As a privileged scaffold, it has its unique chemical properties and …

Abstract Background Pyrazoles, thiazoles and 1, 3, 4-thiadiazoles have been reported to
possess various pharmacological activities. Results An efficient and a novel approach for …

We designed and synthesized the 1, 3, 4-thiadiazole derivatives differing in the structure of
the substituents in C2 and C5 positions. The cytotoxic activity of the obtained compounds …

A new set of laterally OCH3-substituted photoactive liquid crystalline analogues, 4-hexyloxy
phenyl-imino-4ʹ-(3-methoxyphenyl)-4ʹ'-alkoxybenzoates, were synthesized and …