[HTML][HTML] Exploring interactions between extracellular vesicles and cells for innovative drug delivery system design

SAA Kooijmans, OG de Jong, RM Schiffelers - Advanced drug delivery …, 2021 - Elsevier
Extracellular vesicles (EVs) are submicron cell-secreted structures containing proteins,
nucleic acids and lipids. EVs can functionally transfer these cargoes from one cell to another …

[HTML][HTML] Epigenomic dysregulation in schizophrenia: in search of disease etiology and biomarkers

B Khavari, MJ Cairns - Cells, 2020 - mdpi.com
Schizophrenia is a severe psychiatric disorder with a complex array of signs and symptoms
that causes very significant disability in young people. While schizophrenia has a strong …

[HTML][HTML] MicroRNAs and epigenetics strategies to reverse breast cancer

MM Rahman, AC Brane, TO Tollefsbol - Cells, 2019 - mdpi.com
Breast cancer is a sporadic disease with genetic and epigenetic components. Genomic
instability in breast cancer leads to mutations, copy number variations, and genetic …

[HTML][HTML] A systematic way to infer the regulation relations of miRNAs on target genes and critical miRNAs in cancers

P Xu, Q Wu, J Yu, Y Rao, Z Kou, G Fang, X Shi… - Frontiers in …, 2020 - frontiersin.org
MicroRNAs (miRNAs) are a class of important non-coding RNAs, which play important roles
in tumorigenesis and development by targeting oncogenes or tumor suppressor genes. One …

[HTML][HTML] Paired miRNA-and messenger RNA-sequencing identifies novel miRNA-mRNA interactions in multiple myeloma

KR Aass, TMV Nedal, SS Tryggestad, E Haukås… - Scientific Reports, 2022 - nature.com
Multiple myeloma (MM) is an incurable cancer of terminally differentiated plasma cells that
proliferate in the bone marrow. miRNAs are promising biomarkers for risk stratification in MM …

HNF4A-AS1-encoded small peptide promotes self-renewal and aggressiveness of neuroblastoma stem cells via eEF1A1-repressed SMAD4 transactivation

H Song, J Wang, X Wang, B Yuan, D Li, A Hu, Y Guo… - Oncogene, 2022 - nature.com
Cancer stem cells play crucial roles in tumorigenesis and aggressiveness, while regulatory
mechanisms in neuroblastoma (NB), a pediatric extracranial malignancy with highest …

Human blastocysts uptake extracellular vesicles secreted by endometrial cells containing miRNAs related to implantation

M Segura-Benítez, A Bas-Rivas… - Human …, 2023 - academic.oup.com
STUDY QUESTION Are the extracellular vesicles (EVs) secreted by the maternal
endometrium uptaken by human embryos and is their miRNA cargo involved in implantation …

Epigenetically regulated gene expression profiles reveal four molecular subtypes with prognostic and therapeutic implications in colorectal cancer

X Wang, J Liu, D Wang, M Feng… - Briefings in …, 2021 - academic.oup.com
Transcriptomic deregulation by epigenetic mechanisms plays a crucial role in the
heterogeneous progression of colorectal cancer (CRC). Herein, we first demonstrated that …

Exosomal microRNAs from mesenchymal stem cells: novel therapeutic effect in wound healing

C Ju, D Liu - Tissue Engineering and Regenerative Medicine, 2023 - Springer
Background: Wound healing is a complicated biological process that leads to the
regeneration of damaged skin tissue. Determining the methods to promote wound healing …

[HTML][HTML] miR-617 interacts with the promoter of DDX27 and positively regulates its expression: implications for cancer therapeutics

N Sarkar, R Mishra, C Gopal, A Kumar - Frontiers in Oncology, 2024 - ncbi.nlm.nih.gov
Background Pervasive transcription of the eukaryotic genome generates noncoding RNAs
(ncRNAs), which regulate messenger RNA (mRNA) stability and translation. MicroRNAs …