Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells
in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer …

Glioblastoma (GBM) is the most common type of primary brain tumor in adults. Despite
recent advances in cancer therapy, including the breakthrough of immunotherapy, the …

Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …

Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …

Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously
demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the …

Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast
cancer and indicate a poor prognosis. These tumors are especially resistant to currently …

While the central nervous system is considered an immunoprivileged site and brain tumors
display immunosuppressive features, both innate and adaptive immune responses affect …

Over the last 60 years an eclectic collection of microbes has been tested in a variety of pre-
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …

Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are
resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus …