Tumor-associated macrophage status in cancer treatment
AM Malfitano, S Pisanti, F Napolitano, S Di Somma… - Cancers, 2020 - mdpi.com
Tumor-associated macrophages (TAMs) represent the most abundant innate immune cells
in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer …
in tumors. TAMs, exhibiting anti-inflammatory phenotype, are key players in cancer …
Virus-based immunotherapy of glioblastoma
M Martikainen, M Essand - Cancers, 2019 - mdpi.com
Glioblastoma (GBM) is the most common type of primary brain tumor in adults. Despite
recent advances in cancer therapy, including the breakthrough of immunotherapy, the …
recent advances in cancer therapy, including the breakthrough of immunotherapy, the …
An oncolytic virus expressing a full-length antibody enhances antitumor innate immune response to glioblastoma
Oncolytic herpes simplex virus-1 is capable of lysing tumor cells while alerting the immune
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …
system. CD47, in collaboration with SIRPα, represents an important immune checkpoint to …
Distinct uptake, amplification, and release of SARS-CoV-2 by M1 and M2 alveolar macrophages
J Lv, Z Wang, Y Qu, H Zhu, Q Zhu, W Tong, L Bao, Q Lv… - Cell discovery, 2021 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) invades the alveoli, where
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …
abundant alveolar macrophages (AMs) reside. How AMs respond to SARS-CoV-2 invasion …
Ang-2/VEGF bispecific antibody reprograms macrophages and resident microglia to anti-tumor phenotype and prolongs glioblastoma survival
J Kloepper, L Riedemann… - Proceedings of the …, 2016 - National Acad Sciences
Inhibition of the vascular endothelial growth factor (VEGF) pathway has failed to improve
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …
overall survival of patients with glioblastoma (GBM). We previously showed that angiopoietin …
Dual inhibition of Ang-2 and VEGF receptors normalizes tumor vasculature and prolongs survival in glioblastoma by altering macrophages
TE Peterson, ND Kirkpatrick, Y Huang… - Proceedings of the …, 2016 - National Acad Sciences
Glioblastomas (GBMs) rapidly become refractory to anti-VEGF therapies. We previously
demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the …
demonstrated that ectopic overexpression of angiopoietin-2 (Ang-2) compromises the …
[HTML][HTML] A combinational therapy of EGFR-CAR NK cells and oncolytic herpes simplex virus 1 for breast cancer brain metastases
Breast cancer brain metastases (BCBMs) are common in patients with metastatic breast
cancer and indicate a poor prognosis. These tumors are especially resistant to currently …
cancer and indicate a poor prognosis. These tumors are especially resistant to currently …
Distribution and prognostic impact of microglia/macrophage subpopulations in gliomas
PS Zeiner, C Preusse, A Golebiewska, J Zinke… - Brain …, 2019 - Wiley Online Library
While the central nervous system is considered an immunoprivileged site and brain tumors
display immunosuppressive features, both innate and adaptive immune responses affect …
display immunosuppressive features, both innate and adaptive immune responses affect …
Oncolytic virus combination therapy: killing one bird with two stones
NT Martin, JC Bell - Molecular Therapy, 2018 - cell.com
Over the last 60 years an eclectic collection of microbes has been tested in a variety of pre-
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …
clinical models as anti-cancer agents. At the forefront of this research are a number of virus …
[HTML][HTML] Zika virus oncolytic activity requires CD8+ T cells and is boosted by immune checkpoint blockade
Glioblastoma multiforme (GBM) is a fatal human cancer in part because GBM stem cells are
resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus …
resistant to therapy and recurrence is inevitable. Previously, we demonstrated Zika virus …