Objective To review the current knowledge on bone health in patients with hemophilia A and
the underlying pathogenetic mechanisms. Data Sources Original research articles, meta …

Joint health is a key contributor to quality of life in patients with hemophilia. However,
variables that impact long-term joint outcomes have not been comprehensively defined. A …

As the major reason for limb dysfunction, osteoarthritis (OA) is closely correlated with the
level of cellular autophagy. PI3K/Akt is a classical signaling pathway which regulates …

Hemophilic arthropathy (HA) is a debilitating degenerative joint disease that is a major
manifestation of the bleeding disorder hemophilia A. HA typically begins with hemophilic …

Background Patients with haemophilia experience recurring hemarthroses, mainly involving
knees, elbows and ankles, which lead to haemophilic arthropathy, the major chronic …

Vascular remodelling is a prominent feature of haemophilic arthropathy (HA) that may
underlie re-bleeding, yet the nature of vascular changes and underlying mechanisms …

Background: Hemophilia A and B are X-linked congenital bleeding disorders characterized
by recurrent hemarthroses leading to specific changes in the synovium and cartilage, which …

Background Persons with nonsevere hemophilia A (NSHA) experience less frequent joint
bleeding than persons with severe hemophilia A, but may still develop joint damage …

Introduction 3D gait analysis has been proposed as a reproducible and valid method to
assess abnormal gait patterns and to monitor disease progression in patients with …

Abstract Systemic Lupus Erythematosus is an autoimmune disease with female
preponderance. Anemia is found in 50% of Systemic Lupus Erythematosus patients. This is …