Humanized mouse models of clinical disease

NC Walsh, LL Kenney, S Jangalwe… - Annual Review of …, 2017 - annualreviews.org
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …

RNAi therapeutic and its innovative biotechnological evolution

Y Weng, H Xiao, J Zhang, XJ Liang, Y Huang - Biotechnology advances, 2019 - Elsevier
Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …

Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2016 recommendations of the International Antiviral Society–USA panel

HF Günthard, MS Saag, CA Benson, C Del Rio, JJ Eron… - Jama, 2016 - jamanetwork.com
Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …

[HTML][HTML] Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond

S Chaudhuri, JA Symons, J Deval - Antiviral research, 2018 - Elsevier
Abstract 2017 marked the 30th anniversary of the approval of zidovudine (AZT) as the first
HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received FDA approval …

[HTML][HTML] Immunological barriers to haematopoietic stem cell gene therapy

CT Charlesworth, I Hsu, AC Wilkinson… - Nature Reviews …, 2022 - nature.com
Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the
transformative potential of regenerative medicine. Recent clinical successes for gene …

[HTML][HTML] Block and lock HIV cure strategies to control the latent reservoir

CL Ahlenstiel, G Symonds, SJ Kent… - Frontiers in cellular and …, 2020 - frontiersin.org
The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …

[HTML][HTML] Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS

A Zhen, CW Peterson, MA Carrillo, SS Reddy… - PLoS …, 2017 - journals.plos.org
Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for
various forms of cancer and show promise in treating HIV-1 infection. However, significant …

[HTML][HTML] CCR5 targeted cell therapy for HIV and prevention of viral escape

G Hütter, J Bodor, S Ledger, M Boyd, M Millington… - Viruses, 2015 - mdpi.com
Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …

CCR5 revisited: how mechanisms of HIV entry govern AIDS pathogenesis

A Brelot, LA Chakrabarti - Journal of Molecular Biology, 2018 - Elsevier
The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …

[HTML][HTML] Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS

CW Peterson, KG Haworth, BP Burke… - … Therapy-Methods & …, 2016 - cell.com
We have focused on gene therapy approaches to induce functional cure/remission of HIV-1
infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral …