Humanized mouse models of clinical disease
NC Walsh, LL Kenney, S Jangalwe… - Annual Review of …, 2017 - annualreviews.org
Immunodeficient mice engrafted with functional human cells and tissues, that is, humanized
mice, have become increasingly important as small, preclinical animal models for the study …
mice, have become increasingly important as small, preclinical animal models for the study …
RNAi therapeutic and its innovative biotechnological evolution
Abstract Recently, United States Food and Drug Administration (FDA) and European
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …
Commission (EC) approved Alnylam Pharmaceuticals' RNA interference (RNAi) therapeutic …
Antiretroviral drugs for treatment and prevention of HIV infection in adults: 2016 recommendations of the International Antiviral Society–USA panel
Importance New data and therapeutic options warrant updated recommendations for the use
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …
of antiretroviral drugs (ARVs) to treat or to prevent HIV infection in adults. Objective To …
[HTML][HTML] Innovation and trends in the development and approval of antiviral medicines: 1987–2017 and beyond
S Chaudhuri, JA Symons, J Deval - Antiviral research, 2018 - Elsevier
Abstract 2017 marked the 30th anniversary of the approval of zidovudine (AZT) as the first
HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received FDA approval …
HIV/AIDS therapy. Since then, more than eighty antiviral drugs have received FDA approval …
[HTML][HTML] Immunological barriers to haematopoietic stem cell gene therapy
Cell and gene therapies using haematopoietic stem cells (HSCs) epitomize the
transformative potential of regenerative medicine. Recent clinical successes for gene …
transformative potential of regenerative medicine. Recent clinical successes for gene …
[HTML][HTML] Block and lock HIV cure strategies to control the latent reservoir
CL Ahlenstiel, G Symonds, SJ Kent… - Frontiers in cellular and …, 2020 - frontiersin.org
The HIV latent reservoir represents the major challenge to cure development. Residing in
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …
resting CD4+ T cells and myeloid cells at multiple locations in the body, including sanctuary …
[HTML][HTML] Long-term persistence and function of hematopoietic stem cell-derived chimeric antigen receptor T cells in a nonhuman primate model of HIV/AIDS
A Zhen, CW Peterson, MA Carrillo, SS Reddy… - PLoS …, 2017 - journals.plos.org
Chimeric Antigen Receptor (CAR) T-cells have emerged as a powerful immunotherapy for
various forms of cancer and show promise in treating HIV-1 infection. However, significant …
various forms of cancer and show promise in treating HIV-1 infection. However, significant …
[HTML][HTML] CCR5 targeted cell therapy for HIV and prevention of viral escape
G Hütter, J Bodor, S Ledger, M Boyd, M Millington… - Viruses, 2015 - mdpi.com
Allogeneic transplantation with CCR5-delta 32 (CCR5-d32) homozygous stem cells in an
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …
HIV infected individual in 2008, led to a sustained virus control and probably eradication of …
CCR5 revisited: how mechanisms of HIV entry govern AIDS pathogenesis
A Brelot, LA Chakrabarti - Journal of Molecular Biology, 2018 - Elsevier
The chemokine receptor CCR5 has been the focus of intensive studies since its role as a
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
coreceptor for HIV entry was discovered in 1996. These studies lead to the development of …
[HTML][HTML] Multilineage polyclonal engraftment of Cal-1 gene-modified cells and in vivo selection after SHIV infection in a nonhuman primate model of AIDS
CW Peterson, KG Haworth, BP Burke… - … Therapy-Methods & …, 2016 - cell.com
We have focused on gene therapy approaches to induce functional cure/remission of HIV-1
infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral …
infection. Here, we evaluated the safety and efficacy of the clinical grade anti-HIV lentiviral …