A guide to the composition and functions of the extracellular matrix
Extracellular matrix (ECM) is a dynamic 3‐dimensional network of macromolecules that
provides structural support for the cells and tissues. Accumulated knowledge clearly …
provides structural support for the cells and tissues. Accumulated knowledge clearly …
Hyaluronic acid: redefining its role
G Abatangelo, V Vindigni, G Avruscio, L Pandis, P Brun - Cells, 2020 - mdpi.com
The discovery of several unexpected complex biological roles of hyaluronic acid (HA) has
promoted new research impetus for biologists and, the clinical interest in several fields of …
promoted new research impetus for biologists and, the clinical interest in several fields of …
Promotion of cholangiocarcinoma growth by diverse cancer-associated fibroblast subpopulations
Cancer-associated fibroblasts (CAF) are a poorly characterized cell population in the context
of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma …
of liver cancer. Our study investigates CAF functions in intrahepatic cholangiocarcinoma …
How the ageing microenvironment influences tumour progression
M Fane, AT Weeraratna - Nature Reviews Cancer, 2020 - nature.com
Most cancers arise in individuals over the age of 60. As the world population is living longer
and reaching older ages, cancer is becoming a substantial public health problem. It is …
and reaching older ages, cancer is becoming a substantial public health problem. It is …
Hyaluronic acid: A review on its biology, aspects of drug delivery, route of administrations and a special emphasis on its approved marketed products and recent …
Hyaluronic acid (HA) is a large non-sulphated glycosaminoglycan that is an important
component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in …
component of extracellular matrix (ECM) and a biodegradable polymer. Due to a variation in …
YTHDF1 links hypoxia adaptation and non-small cell lung cancer progression
Y Shi, S Fan, M Wu, Z Zuo, X Li, L Jiang, Q Shen… - Nature …, 2019 - nature.com
Hypoxia occurs naturally at high-altitudes and pathologically in hypoxic solid tumors. Here,
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …
we report that genes involved in various human cancers evolved rapidly in Tibetans and six …
Cancer drug resistance induced by EMT: novel therapeutic strategies
J De Las Rivas, A Brozovic, S Izraely, A Casas-Pais… - Archives of …, 2021 - Springer
Over the last decade, important clinical benefits have been achieved in cancer patients by
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …
using drug-targeting strategies. Nevertheless, drug resistance is still a major problem in …
Hyaluronan: molecular size‐dependent signaling and biological functions in inflammation and cancer
AG Tavianatou, I Caon, M Franchi… - The FEBS …, 2019 - Wiley Online Library
Hyaluronan (HA) is a linear nonsulfated glycosaminoglycan of the extracellular matrix that
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …
plays a pivotal role in a variety of biological processes. High‐molecular weight HA exhibits …
Increased hyaluronan by naked mole-rat Has2 improves healthspan in mice
Abundant high-molecular-mass hyaluronic acid (HMM-HA) contributes to cancer resistance
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
and possibly to the longevity of the longest-lived rodent—the naked mole-rat,. To study …
Remodelling the extracellular matrix in development and disease
The extracellular matrix (ECM) is a highly dynamic structure that is present in all tissues and
continuously undergoes controlled remodelling. This process involves quantitative and …
continuously undergoes controlled remodelling. This process involves quantitative and …