Zebrafish (Danio rerio) have become a powerful tool in neuroscience research due to their
genetic tractability, molecular/physiological conservation, small body size, ease of …

Zebrafish are increasingly being utilized as a model system to investigate the function of the
growing list of risk genes associated with neurodevelopmental disorders. This is due in large …

Despite the high prevalence of neuropsychiatric disorders, their aetiology and molecular
mechanisms remain poorly understood. The zebrafish (Danio rerio) is increasingly utilized …

Abstract Mutations in Munc18‐1/STXBP1 (syntaxin‐binding protein 1) are linked to various
severe early epileptic encephalopathies and neurodevelopmental disorders. Heterozygous …

Over the last decade, the zebrafish (Danio rerio) has emerged as a model organism for
cardiovascular research. Zebrafish have several advantages over mammalian models. For …

Zebrafish are now widely accepted as a valuable animal model for a number of different
central nervous system (CNS) diseases. They are suitable both for elucidating the origin of …

De novo heterozygous mutations in STXBP1/Munc18-1 cause early infantile epileptic
encephalopathies (EIEE4, OMIM# 612164) characterized by infantile epilepsy …

Genetic engineering techniques have contributed to the now widespread use of zebrafish to
investigate gene function, but zebrafish-based human disease studies, and particularly for …

Pyridoxine-dependent epilepsy (PDE) is a severe neonatal seizure disorder and is here
modeled in aldh7a1-/-zebrafish. Mutant larvae display spontaneous.. Pyridoxine-dependent …

Heterozygous de novo mutations in the neuronal protein Munc18-1 are linked to epilepsies,
intellectual disability, movement disorders, and neurodegeneration. These devastating …