The dentate gyrus of the mammalian hippocampus continuously generates new neurons
during adulthood. These adult-born neurons become functionally active and are thought to …

Alzheimer's disease (AD) is an aging-related neurological disorder characterized by
synaptic loss and dementia. Wnt/β-catenin signaling is an essential signal transduction …

We provide protocols for preparing low-density dissociated-cell cultures of hippocampal
neurons from embryonic rats or mice. The neurons are cultured on polylysine-treated …

Type-specific dendrite morphology is a hallmark of the neuron and has important functional
implications in determining what signals a neuron receives and how these signals are …

Activity-dependent plasticity of vertebrate neurons allows the brain to respond to its
environment. During brain development, both spontaneous and sensory-driven neural …

Sensory experience and the resulting synaptic activity within the brain are critical for the
proper development of neural circuits. Experience-driven synaptic activity causes membrane …

The roles of the Wnt signalling pathway in several developmental processes, including
synaptic differentiation, are well characterized. The expression of Wnt ligands and Wnt …

Wnts comprise a large family of proteins that have shown to be part of a signaling cascade
that regulates several aspects of development including organogenesis, midbrain …

One of the unique characteristics of higher organisms is their ability to learn and adapt to
changes in their environment. This plasticity is largely a result of the brain's ability to convert …

Mutations or duplications in MECP2 cause Rett and Rett-like syndromes,
neurodevelopmental disorders characterized by mental retardation, motor dysfunction, and …