The role of oxidative stress in atherosclerosis
M Batty, MR Bennett, E Yu - Cells, 2022 - mdpi.com
Atherosclerosis is a chronic inflammatory disease of the vascular system and is the leading
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …
cause of cardiovascular diseases worldwide. Excessive generation of reactive oxygen …
[HTML][HTML] Inflammation and cardiovascular disease: From mechanisms to therapeutics
Inflammation constitutes a complex, highly conserved cascade of molecular and cellular
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …
events. Inflammation has been labeled as “the fire within,” is highly regulated, and is critical …
Effects of randomized treatment with icosapent ethyl and a mineral oil comparator on interleukin-1β, interleukin-6, C-reactive protein, oxidized low-density lipoprotein …
Background: REDUCE-IT (Reduction of Cardiovascular Events With Icosapent Ethyl—
Intervention Trial) reported a 25% relative risk reduction in major adverse cardiovascular …
Intervention Trial) reported a 25% relative risk reduction in major adverse cardiovascular …
Drug repurposing: progress, challenges and recommendations
Given the high attrition rates, substantial costs and slow pace of new drug discovery and
development, repurposing of'old'drugs to treat both common and rare diseases is …
development, repurposing of'old'drugs to treat both common and rare diseases is …
The immunology of atherosclerosis
A Gisterå, GK Hansson - Nature reviews nephrology, 2017 - nature.com
Cardiovascular disease is the leading cause of death worldwide, both in the general
population and among patients with chronic kidney disease (CKD). In most cases, the …
population and among patients with chronic kidney disease (CKD). In most cases, the …
Interleukin-1 beta as a target for atherosclerosis therapy: biological basis of CANTOS and beyond
P Libby - Journal of the American College of Cardiology, 2017 - jacc.org
Inflammatory pathways drive atherogenesis and link conventional risk factors to
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …
atherosclerosis and its complications. One inflammatory mediator has come to the fore as a …
Genetic contributions to NAFLD: leveraging shared genetics to uncover systems biology
Nonalcoholic fatty liver disease (NAFLD) affects around a quarter of the global population,
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …
paralleling worldwide increases in obesity and metabolic syndrome. NAFLD arises in the …
Role of inflammation in the pathogenesis of atherosclerosis and therapeutic interventions
Abstract Rudolph Virchow (1821–1902) recognized inflammation in histological
preparations of coronary arteries and proposed that inflammation plays a causal role in …
preparations of coronary arteries and proposed that inflammation plays a causal role in …
Genetics of coronary artery disease: discovery, biology and clinical translation
AV Khera, S Kathiresan - Nature Reviews Genetics, 2017 - nature.com
Coronary artery disease is the leading global cause of mortality. Long recognized to be
heritable, recent advances have started to unravel the genetic architecture of the disease …
heritable, recent advances have started to unravel the genetic architecture of the disease …
Mendelian randomization in cardiometabolic disease: challenges in evaluating causality
Mendelian randomization (MR) is a burgeoning field that involves the use of genetic variants
to assess causal relationships between exposures and outcomes. MR studies can be …
to assess causal relationships between exposures and outcomes. MR studies can be …