Unicellular organisms respond to the presence of DNA lesions by activating cell cycle
checkpoint and repair mechanisms, while multicellular animals have acquired the further …

The p53 tumor suppressor protein is involved in multiple central cellular processes,
including transcription, DNA repair, genomic stability, senescence, cell cycle control, and …

From its modest beginnings in 1979, as a transformation-associated protein, to the
discoveries that p53 plays a key role in tumour suppression and in the cellular response to …

The double-strand break (DSB) is believed to be one of the most severe types of DNA
damage, and if left unrepaired is lethal to the cell. Several different types of repair act on the …

RecA in Escherichia coli and its homolog, ScRad51 in Saccharomyces cerevisiae, are
known to be essential for recombinational repair. The homolog of RecA and ScRad51 in …

The major established cause of acute myeloid leukemia (AML) in the young is cancer
chemotherapy. There are two forms of treatment-related AML (t-AML). Each form has a de …

The tumor suppressor gene p53 plays a major role in regulation of the mammalian cellular
stress response, in part through the transcriptional activation of genes involved in cell cycle …

Volume 58 Issue 18 | Cancer Research | American Association for Cancer Research Skip to
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Abstract p53 has pleiotropic functions including control of genomic plasticity and integrity.
Here we report that p53 can bind to several transcription factor IIH–associated factors …

Germline mutations of the Brca1 gene are responsible for most cases of familial breast and
ovarian cancers, but somatic mutations are rarely detected in sporadic events. Moreover …