Viral vectors provide an efficient means for modification of eukaryotic cells, and their use is
now commonplace in academic laboratories and industry for both research and clinical …

To complete its life cycle, HIV-1 enters the nucleus of the host cell as reverse-transcribed
viral DNA. The nucleus is a complex environment, in which chromatin is organized to …

Although prime editors (PEs) have the potential to facilitate precise genome editing in
therapeutic, agricultural and research applications, their specificity has not been …

Human immunodeficiency virus (HIV) infection is currently incurable, due to the persistence
of latently infected cells. The 'shock and kill'approach to a cure proposes to eliminate this …

Every animal grows from a single fertilized egg into an intricate network of cell types and
organ systems. This process is captured in a lineage tree: a diagram of every cell's ancestry …

Allogeneic CD19-specific chimeric antigen receptor (CAR) T cells with inactivated donor T
cell receptor (TCR) expression can be used as an" off-the-shelf" therapeutic modality for …

Genome editing represents a promising strategy for the therapeutic correction of COL7A1
mutations that cause recessive dystrophic epidermolysis bullosa (RDEB). DNA cleavage …

After invasion of a susceptible target cell, HIV-1 completes the early phase of its life cycle
upon integration of reverse-transcribed viral DNA into host chromatin. The viral capsid, a …

HIV-1 persists lifelong in memory cells of the immune system as latent provirus that
rebounds upon treatment interruption. Therefore, the latent reservoir is the main target for an …

Although HIV-1 replication can be efficiently suppressed to undetectable levels in peripheral
blood by combination antiretroviral therapy (cART), lifelong medication is still required in …