malERA: an updated research agenda for malaria elimination and eradication

RN Rabinovich, C Drakeley, AA Djimde, BF Hall… - PLoS …, 2017 - journals.plos.org
Achieving a malaria-free world presents exciting scientific challenges as well as
overwhelming health, equity, and economic benefits. WHO and countries are setting …

Plasmodium species: master renovators of their host cells

TF de Koning-Ward, MWA Dixon, L Tilley… - Nature Reviews …, 2016 - nature.com
Plasmodium parasites, the causative agents of malaria, have developed elaborate
strategies that they use to survive and thrive within different intracellular environments …

Malaria parasite translocon structure and mechanism of effector export

CM Ho, JR Beck, M Lai, Y Cui, DE Goldberg, PF Egea… - Nature, 2018 - nature.com
The putative Plasmodium translocon of exported proteins (PTEX) is essential for transport of
malarial effector proteins across a parasite-encasing vacuolar membrane into host …

[HTML][HTML] The Toxoplasma dense granule proteins GRA17 and GRA23 mediate the movement of small molecules between the host and the parasitophorous vacuole

DA Gold, AD Kaplan, A Lis, GCL Bett, EE Rosowski… - Cell host & …, 2015 - cell.com
Toxoplasma gondii is a protozoan pathogen in the phylum Apicomplexa that resides within
an intracellular parasitophorous vacuole (PV) that is selectively permeable to small …

EXP2 is a nutrient-permeable channel in the vacuolar membrane of Plasmodium and is essential for protein export via PTEX

M Garten, AS Nasamu, JC Niles, J Zimmerberg… - Nature …, 2018 - nature.com
Intraerythrocytic malaria parasites reside within a parasitophorous vacuolar membrane
(PVM) generated during host cell invasion. Erythrocyte remodelling and parasite metabolism …

A Novel Secreted Protein, MYR1, Is Central to Toxoplasma's Manipulation of Host Cells

M Franco, MW Panas, ND Marino, MCW Lee… - MBio, 2016 - Am Soc Microbiol
The intracellular protozoan Toxoplasma gondii dramatically reprograms the transcriptome of
host cells it infects, including substantially up-regulating the host oncogene c-myc. By …

Clathrin-mediated endocytosis facilitates the internalization of Magnaporthe oryzae effectors into rice cells

E Oliveira-Garcia, TM Tamang, J Park, M Dalby… - The Plant …, 2023 - academic.oup.com
Fungi and oomycetes deliver effectors into living plant cells to suppress defenses and
control plant processes needed for infection. Little is known about the mechanism by which …

Advances in molecular genetic systems in malaria

TF de Koning-Ward, PR Gilson, BS Crabb - Nature Reviews …, 2015 - nature.com
Robust tools for analysing gene function in Plasmodium parasites, which are the causative
agents of malaria, are being developed at an accelerating rate. Two decades after genetic …

EXP1 is critical for nutrient uptake across the parasitophorous vacuole membrane of malaria parasites

P Mesén-Ramírez, B Bergmann, TT Tran, M Garten… - PLoS …, 2019 - journals.plos.org
Intracellular malaria parasites grow in a vacuole delimited by the parasitophorous vacuolar
membrane (PVM). This membrane fulfils critical roles for survival of the parasite in its …

Plasmodium falciparum parasites deploy RhopH2 into the host erythrocyte to obtain nutrients, grow and replicate

NA Counihan, SA Chisholm, HE Bullen, A Srivastava… - Elife, 2017 - elifesciences.org
Plasmodium falciparum parasites, the causative agents of malaria, modify their host
erythrocyte to render them permeable to supplementary nutrient uptake from the plasma and …