Clathrin-mediated endocytosis is a key process in vesicular trafficking that transports a wide
range of cargo molecules from the cell surface to the interior. Clathrin-mediated endocytosis …

Phosphoinositides (PIs) make up only a small fraction of cellular phospholipids, yet they
control almost all aspects of a cell's life and death. These lipids gained tremendous research …

Inositol phospholipids have long been known to have an important regulatory role in cell
physiology. The repertoire of cellular processes known to be directly or indirectly controlled …

Neurons can sustain high rates of synaptic transmission without exhausting their supply of
synaptic vesicles. This property relies on a highly efficient local endocytic recycling of …

n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

Abstract Phosphatidylinositol 4, 5-bisphosphate (PIP2), which comprises only about 1% of
the phospholipids in the cytoplasmic leaflet of the plasma membrane, is the source of three …

Lipidomics aims to quantitatively define lipid classes, including their molecular species, in
biological systems. Lipidomics has experienced rapid progress, mainly because of …

There are numerous studies that suggest multiple links between the cellular
phosphoinositide system and cancer. As key roles in cancer have been established for PI3K …

Lipids are the most abundant organic compounds in the brain. The brain has a unique
lipidome, and changes in lipid concentration, organization, and metabolism are associated …

Fusion of vesicles into target membranes during many types of regulated exocytosis
requires both SNARE-complex proteins and fusogenic lipids, such as phosphatidic acid …