Sumoylation is an essential post-translational modification that is catalysed by a small
number of modifying enzymes but regulates thousands of target proteins in a dynamic …

Both ubiquitination and SUMOylation are dynamic post-translational modifications that
regulate thousands of target proteins to control virtually every cellular process …

The post-translational modification of proteins with ubiquitin (Ub) and Ub-like modifiers
(Ubls) represents one of the most important regulators in eukaryotic biology. Polymeric …

The central dogma of modern biology underscores the pivotal roles proteins play in diverse
biological processes, the study of which necessitates advanced methods to produce …

Solid phase peptide synthesis (SPPS) provides the possibility to chemically synthesize
peptides and proteins. Applying the method on hydrophilic structures is usually without …

Deposits of the microtubule-associated protein Tau (MAPT) serve as a hallmark of
neurodegenerative diseases known as tauopathies. Numerous studies have demonstrated …

Organic chemistry allows for the modification and chemical preparation of protein analogues
for various studies. The thiolate side chain of the Cys residue has been a key functionality in …

Activity-based probes (ABPs) are widely used to monitor the activity of enzyme families in
biological systems. Inferring enzyme activity from probe reactivity requires that the probe …

Conspectus Chemical protein synthesis has been proved as an efficient way to afford
medium-sized proteins with high homogeneity in workable quantities for various …

Live‐cell delivery of a fully synthetic protein having selectivity towards a particular target is a
promising approach with potential applications for basic research and therapeutics. Cell …