The intricate molecular pathways governing cancer development and progression have
spurred intensive investigations into novel therapeutic targets. Glycogen Synthase Kinase-3 …

Elevated circulating glucose level due to β-cell dysfunction has been a key marker of Type-II
diabetes. Glycogen synthase kinase-3 (GSK-3) has been recognized as an enzyme involved …

Small-molecule-inhibitor-based bone differentiation has been recently exploited as a novel
approach to regulating osteogenesis-related signaling pathways. In this study, we identified …

Hearing loss is a severe high unmet need condition affecting more than 1.5 billion people
globally. There are no licensed medicines for the prevention, treatment or restoration of …

Ethnopharmacological relevance Asthma is a chronic airway inflammatory disease that can
lead to several complications caused by bacterial infections. However, recurrent attacks of …

Abstract Glycogen synthase kinase 3 (GSK-3) is a highly conserved protein serine/threonine
kinase that plays a central role in a wide variety of cellular processes to coordinate catabolic …

Alzheimer's disease (AD) is a neurodegenerative disorder associated with the dysregulation
of several key enzymes, including acetylcholinesterase (AChE), cyclooxygenase-2 (COX-2) …

Abstract Glycogen synthase kinase 3 (GSK3) is associated with the proinflammatory
phenotype of microglia and has been shown to act in concert with nuclear factor kappa B …

Acute lung injury (ALI) is an intricate clinical disease marked by high mortality and a sudden
start. Currently, although there are no specific therapeutics for ALI, the administration of anti …

Aeromonas hydrophila is a significant pathogen in the field of fish farming, resulting in
substantial financial losses for the aquaculture industry. As the pathogen's resistance to …