Using small non-coding RNAs in extracellular vesicles of semen as biomarkers of male reproductive system health: opportunities and challenges

S Larriba, F Vigués, L Bassas - International Journal of Molecular …, 2023 - mdpi.com
Reproductive dysfunction and urogenital malignancies represent a serious health concern
in men. This is in part as a result of the absence of reliable non-invasive tests of …

Promising novel biomarkers and therapy targets: The application of cell-free seminal nucleotides in male reproduction research

HM Li, XY Wan, JY Zhao, XM Liang, Y Dai, HG Li - Translational Research, 2023 - Elsevier
Liquid biopsy has the advantage of diagnosing diseases in a non-invasive manner. Seminal
plasma contains secretions from the bilateral testes, epididymides, seminal vesicles …

Motility-related microRNAs identified in pig seminal plasma exosomes by high-throughput small RNA sequencing

Y Zhao, J Qin, J Sun, J He, Y Sun, R Yuan, Z Li - Theriogenology, 2024 - Elsevier
Boar fertility is a key determinant of the production efficiency of the whole pig breeding
industry and boar sperm motility is the seminal parameter with the greatest impact on the …

[HTML][HTML] Obesity and male fertility disorders

R Cannarella, A Crafa, R Curto, RA Condorelli… - Molecular Aspects of …, 2024 - Elsevier
Often associated with obesity, male infertility represents a widespread condition that
challenges the wellbeing of the couple. In this article, we provide a comprehensive and …

Human sperm RNA in male infertility

R Cannarella, A Crafa, R Curto, LM Mongioì… - Nature Reviews …, 2024 - nature.com
The function and value of specific sperm RNAs in apparently idiopathic male infertility are
currently poorly understood. Whether differences exist in the sperm RNA profile between …

Non-invasive biomarkers for sperm retrieval in non-obstructive patients: a comprehensive review

L Fontana, SM Sirchia, C Pesenti, GM Colpi… - Frontiers in …, 2024 - frontiersin.org
Recent advancements in reproductive medicine have guided novel strategies for addressing
male infertility, particularly in cases of non-obstructive azoospermia (NOA). Two prominent …

Intraindividual variability of semen quality, proteome, and sncRNA profiles in a healthy cohort of young adults

O Sergeyev, V Bezuglov, N Soloveva, L Smigulina… - …, 2024 - Wiley Online Library
Background Within‐subject variability of semen parameters and molecular components of
ejaculates in young men remains poorly understood. Objectives To investigate …

Approaches for sRNA analysis of human RNA-seq data: comparison, benchmarking

V Bezuglov, A Stupnikov, I Skakov… - International Journal of …, 2023 - mdpi.com
Expression analysis of small noncoding RNA (sRNA), including microRNA, piwi-interacting
RNA, small rRNA-derived RNA, and tRNA-derived small RNA, is a novel and quickly …

Urinary phthalate metabolites and small non-coding RNAs from seminal plasma extracellular vesicles among men undergoing infertility treatment

OA Oluwayiose, E Houle, BW Whitcomb… - Environmental …, 2023 - Elsevier
Non-coding RNA (ncRNA) cargo of extracellular vesicles (EVs) in the male reproductive tract
play critical roles in semen quality and emerging evidence suggests their susceptibility to …

Small RNAs in andrology: Small messengers with large perspectives.

K Almstrup - Andrology, 2023 - search.ebscohost.com
Small non-coding RNA sequencing reveals global dysregulation of piwi-interacting RNA
(piRNA) expression in gonadal malignant germ cell tumours. Since the discovery of …