Proteogenomic data and resources for pan-cancer analysis
Summary The National Cancer Institute's Clinical Proteomic Tumor Analysis Consortium
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
(CPTAC) investigates tumors from a proteogenomic perspective, creating rich multi-omics …
[HTML][HTML] Integrative multi-omic cancer profiling reveals DNA methylation patterns associated with therapeutic vulnerability and cell-of-origin
DNA methylation plays a critical role in establishing and maintaining cellular identity.
However, it is frequently dysregulated during tumor development and is closely intertwined …
However, it is frequently dysregulated during tumor development and is closely intertwined …
[HTML][HTML] Pan-cancer analysis of post-translational modifications reveals shared patterns of protein regulation
Post-translational modifications (PTMs) play key roles in regulating cell signaling and
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
physiology in both normal and cancer cells. Advances in mass spectrometry enable high …
Neutrophil profiling illuminates anti-tumor antigen-presenting potency
Y Wu, J Ma, X Yang, F Nan, T Zhang, S Ji, D Rao… - Cell, 2024 - cell.com
Neutrophils, the most abundant and efficient defenders against pathogens, exert opposing
functions across cancer types. However, given their short half-life, it remains challenging to …
functions across cancer types. However, given their short half-life, it remains challenging to …
Tumor initiation and early tumorigenesis: molecular mechanisms and interventional targets
S Zhang, X Xiao, Y Yi, X Wang, L Zhu, Y Shen… - … and Targeted Therapy, 2024 - nature.com
Tumorigenesis is a multistep process, with oncogenic mutations in a normal cell conferring
clonal advantage as the initial event. However, despite pervasive somatic mutations and …
clonal advantage as the initial event. However, despite pervasive somatic mutations and …
[HTML][HTML] DNA methylation profiles in cancer: functions, therapy, and beyond
J Zhu, Y Yang, L Li, J Tang, R Zhang - Cancer Biology & Medicine, 2024 - ncbi.nlm.nih.gov
DNA methylation, a reversible post-replication modification, defines gene expression and
function in different physiologic processes. Hypomethylation is quite common among global …
function in different physiologic processes. Hypomethylation is quite common among global …
Calcium signaling in cancer immunity
C Amantini, MB Morelli - Frontiers in Immunology, 2023 - frontiersin.org
It is now widely recognized that Ca2+ represents an important and universal second
messenger responsible for the regulation of various cellular processes such as proliferation …
messenger responsible for the regulation of various cellular processes such as proliferation …
Multi-scale signaling and tumor evolution in high-grade gliomas
Although genomic anomalies in glioblastoma (GBM) have been well studied for over a
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …
decade, its 5-year survival rate remains lower than 5%. We seek to expand the molecular …
Illuminating function of the understudied druggable kinome
The human kinome, with more than 500 proteins, is crucial for cell signaling and disease.
Yet, about one-third of kinases lack in-depth study. The Data and Resource Generating …
Yet, about one-third of kinases lack in-depth study. The Data and Resource Generating …
Time-Resolved Ultraviolet Photodissociation Mass Spectrometry Probes the Mutation-Induced Alterations in Protein Stability and Unfolding Dynamics
How mutations impact protein stability and structure dynamics is crucial for understanding
the pathological process and rational drug design. Herein, we establish a time-resolved …
the pathological process and rational drug design. Herein, we establish a time-resolved …